1r09
From Proteopedia
(New page: 200px<br /><applet load="1r09" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r09, resolution 2.9Å" /> '''HUMAN RHINOVIRUS 14 C...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1r09.jpg|left|200px]]<br /><applet load="1r09" size=" | + | [[Image:1r09.jpg|left|200px]]<br /><applet load="1r09" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1r09, resolution 2.9Å" /> | caption="1r09, resolution 2.9Å" /> | ||
'''HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837'''<br /> | '''HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The binding of the antirhinoviral agent R 61837 to human rhinovirus 14 has | + | The binding of the antirhinoviral agent R 61837 to human rhinovirus 14 has been examined by X-ray crystallographic methods. The compound R 61837 binds in the same pocket (underneath the canyon floor) as the "WIN" antirhinoviral agents. It does not penetrate as far into the pocket but causes similar conformational changes in the virus capsid. The movement of residues 1217 to 1221 of viral protein 1 (in the "FMDV loop") is more pronounced for R 61837 than for WIN compounds. Although both R 61837 and WIN antiviral agents partially fill the same hydrophobic pocket, atomic binding interactions differ, showing that considerable diversity in the nature of antiviral agents is possible. |
==About this Structure== | ==About this Structure== | ||
| - | 1R09 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_10 Human rhinovirus 10] with JEN and DMS as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1R09 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_10 Human rhinovirus 10] with <scene name='pdbligand=JEN:'>JEN</scene> and <scene name='pdbligand=DMS:'>DMS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R09 OCA]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Andries, K.]] | [[Category: Andries, K.]] | ||
| - | [[Category: Chapman, M | + | [[Category: Chapman, M S.]] |
| - | [[Category: Diana, G | + | [[Category: Diana, G D.]] |
[[Category: Minor, I.]] | [[Category: Minor, I.]] | ||
| - | [[Category: Rossmann, M | + | [[Category: Rossmann, M G.]] |
[[Category: DMS]] | [[Category: DMS]] | ||
[[Category: JEN]] | [[Category: JEN]] | ||
| Line 23: | Line 23: | ||
[[Category: rhinovirus coat protein]] | [[Category: rhinovirus coat protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:45:36 2008'' |
Revision as of 12:45, 21 February 2008
|
HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837
Overview
The binding of the antirhinoviral agent R 61837 to human rhinovirus 14 has been examined by X-ray crystallographic methods. The compound R 61837 binds in the same pocket (underneath the canyon floor) as the "WIN" antirhinoviral agents. It does not penetrate as far into the pocket but causes similar conformational changes in the virus capsid. The movement of residues 1217 to 1221 of viral protein 1 (in the "FMDV loop") is more pronounced for R 61837 than for WIN compounds. Although both R 61837 and WIN antiviral agents partially fill the same hydrophobic pocket, atomic binding interactions differ, showing that considerable diversity in the nature of antiviral agents is possible.
About this Structure
1R09 is a Protein complex structure of sequences from Human rhinovirus 10 with and as ligands. Full crystallographic information is available from OCA.
Reference
Human rhinovirus 14 complexed with antiviral compound R 61837., Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K, J Mol Biol. 1991 Feb 5;217(3):455-63. PMID:1847215
Page seeded by OCA on Thu Feb 21 14:45:36 2008
