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1r2q
From Proteopedia
(New page: 200px<br /> <applet load="1r2q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r2q, resolution 1.05Å" /> '''Crystal Structure o...) |
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| - | [[Image:1r2q.gif|left|200px]]<br /> | + | [[Image:1r2q.gif|left|200px]]<br /><applet load="1r2q" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1r2q" size=" | + | |
caption="1r2q, resolution 1.05Å" /> | caption="1r2q, resolution 1.05Å" /> | ||
'''Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution'''<br /> | '''Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Rab5 is a GTPase that regulates early endosome fusion. Its GTPase domain | + | Rab5 is a GTPase that regulates early endosome fusion. Its GTPase domain crystal structure is reported here at 1.05 A resolution in complex with a GTP-analog molecule. It provides the highest resolution three-dimensional model so far obtained for proteins from the Ras-like GTPase family. This study allows extension of structural examination of the GTPase machinery as well as of high-resolution protein structures in general. For example, a buried water-molecule network was observed underneath the switch regions, which is consistent with the functional roles of these regions in the molecular-switching process. Furthermore, residues of multiple conformation and clustered distribution of anisotropic thermal motions of the protein molecule may have general implications for the function of Ras-like GTPases. |
==About this Structure== | ==About this Structure== | ||
| - | 1R2Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG, GNP and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1R2Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=GNP:'>GNP</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2Q OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Li, G.]] | [[Category: Li, G.]] | ||
[[Category: Terzyan, S.]] | [[Category: Terzyan, S.]] | ||
| - | [[Category: Zhang, X | + | [[Category: Zhang, X C.]] |
[[Category: Zhu, G.]] | [[Category: Zhu, G.]] | ||
[[Category: GNP]] | [[Category: GNP]] | ||
| Line 26: | Line 25: | ||
[[Category: rab]] | [[Category: rab]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:46:25 2008'' |
Revision as of 12:46, 21 February 2008
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Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution
Overview
Rab5 is a GTPase that regulates early endosome fusion. Its GTPase domain crystal structure is reported here at 1.05 A resolution in complex with a GTP-analog molecule. It provides the highest resolution three-dimensional model so far obtained for proteins from the Ras-like GTPase family. This study allows extension of structural examination of the GTPase machinery as well as of high-resolution protein structures in general. For example, a buried water-molecule network was observed underneath the switch regions, which is consistent with the functional roles of these regions in the molecular-switching process. Furthermore, residues of multiple conformation and clustered distribution of anisotropic thermal motions of the protein molecule may have general implications for the function of Ras-like GTPases.
About this Structure
1R2Q is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution., Terzyan S, Zhu G, Li G, Zhang XC, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):54-60. Epub 2003, Dec 18. PMID:14684892
Page seeded by OCA on Thu Feb 21 14:46:25 2008
Categories: Homo sapiens | Single protein | Li, G. | Terzyan, S. | Zhang, X C. | Zhu, G. | GNP | GOL | MG | Atomic resolution | Gnp | Gtpase | Rab
