1r3m
From Proteopedia
(New page: 200px<br /><applet load="1r3m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r3m, resolution 2.2Å" /> '''Crystal structure of ...) |
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| - | [[Image:1r3m.gif|left|200px]]<br /><applet load="1r3m" size=" | + | [[Image:1r3m.gif|left|200px]]<br /><applet load="1r3m" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1r3m, resolution 2.2Å" /> | caption="1r3m, resolution 2.2Å" /> | ||
'''Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease'''<br /> | '''Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Bovine seminal ribonuclease is a unique case of protein dimorphism, since | + | Bovine seminal ribonuclease is a unique case of protein dimorphism, since it exists in two dimeric forms, with different biological and kinetic behavior, which interconvert into one another through three-dimensional swapping. Here we report the crystal structure, at 2.2 A resolution, of the unswapped form of bovine seminal ribonuclease. Besides completing the structural definition of bovine seminal ribonuclease conformational dimorphism, this study provides the structural basis to explain the dependence of the enzyme cooperative effects on its swapping state. |
==About this Structure== | ==About this Structure== | ||
| - | 1R3M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http:// | + | 1R3M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R3M OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Berisio, R.]] | [[Category: Berisio, R.]] | ||
| - | [[Category: Fiore, A | + | [[Category: Fiore, A Di.]] |
| - | [[Category: Lorenzo, C | + | [[Category: Lorenzo, C De.]] |
[[Category: Mazzarella, L.]] | [[Category: Mazzarella, L.]] | ||
[[Category: Piccoli, R.]] | [[Category: Piccoli, R.]] | ||
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[[Category: swapping]] | [[Category: swapping]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:46:42 2008'' |
Revision as of 12:46, 21 February 2008
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Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease
Overview
Bovine seminal ribonuclease is a unique case of protein dimorphism, since it exists in two dimeric forms, with different biological and kinetic behavior, which interconvert into one another through three-dimensional swapping. Here we report the crystal structure, at 2.2 A resolution, of the unswapped form of bovine seminal ribonuclease. Besides completing the structural definition of bovine seminal ribonuclease conformational dimorphism, this study provides the structural basis to explain the dependence of the enzyme cooperative effects on its swapping state.
About this Structure
1R3M is a Single protein structure of sequence from Bos taurus with as ligand. Active as Pancreatic ribonuclease, with EC number 3.1.27.5 Full crystallographic information is available from OCA.
Reference
Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease., Berisio R, Sica F, De Lorenzo C, Di Fiore A, Piccoli R, Zagari A, Mazzarella L, FEBS Lett. 2003 Nov 6;554(1-2):105-10. PMID:14596923
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