1r54
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Adam33 is a putative asthma susceptibility gene encoding for a | + | Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hammond, G.]] | [[Category: Hammond, G.]] | ||
| - | [[Category: Mirza, U | + | [[Category: Mirza, U A.]] |
[[Category: Orth, P.]] | [[Category: Orth, P.]] | ||
| - | [[Category: Prosise, W | + | [[Category: Prosise, W W.]] |
[[Category: Reicher, P.]] | [[Category: Reicher, P.]] | ||
[[Category: Strickland, C.]] | [[Category: Strickland, C.]] | ||
| - | [[Category: Taremi, S | + | [[Category: Taremi, S S.]] |
[[Category: Wang, W.]] | [[Category: Wang, W.]] | ||
[[Category: Xiao, L.]] | [[Category: Xiao, L.]] | ||
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[[Category: metalloprotease]] | [[Category: metalloprotease]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:47:09 2008'' |
Revision as of 12:47, 21 February 2008
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Crystal structure of the catalytic domain of human ADAM33
Overview
Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme.
About this Structure
1R54 is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745
Page seeded by OCA on Thu Feb 21 14:47:09 2008
Categories: Homo sapiens | Single protein | Hammond, G. | Mirza, U A. | Orth, P. | Prosise, W W. | Reicher, P. | Strickland, C. | Taremi, S S. | Wang, W. | Xiao, L. | Yarosh-Tomaine, T. | Zou, J. | CA | CL | ZN | Adam | Asthma | Metalloprotease
