1rau
From Proteopedia
(New page: 200px<br /><applet load="1rau" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rau" /> '''SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RN...) |
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| - | [[Image:1rau.gif|left|200px]]<br /><applet load="1rau" size=" | + | [[Image:1rau.gif|left|200px]]<br /><applet load="1rau" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES'''<br /> | '''SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has | + | A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40 degrees C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware. |
==About this Structure== | ==About this Structure== | ||
| - | 1RAU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1RAU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RAU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Cheong, C.]] | [[Category: Cheong, C.]] | ||
| - | [[Category: Moore, P | + | [[Category: Moore, P B.]] |
[[Category: nmr]] | [[Category: nmr]] | ||
[[Category: rna]] | [[Category: rna]] | ||
[[Category: tetraplex]] | [[Category: tetraplex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:48:53 2008'' |
Revision as of 12:48, 21 February 2008
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SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES
Overview
A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40 degrees C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware.
About this Structure
1RAU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures., Cheong C, Moore PB, Biochemistry. 1992 Sep 15;31(36):8406-14. PMID:1382577
Page seeded by OCA on Thu Feb 21 14:48:53 2008
Categories: Protein complex | Cheong, C. | Moore, P B. | Nmr | Rna | Tetraplex
