SandboxPKA
From Proteopedia
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<Structure load='3DY7' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='3DY7' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
| - | + | Catalitic subunit of c-Abl protein is composed by two different regions: | |
| + | |||
| + | Dentro del core de la akt, tenemos dos regiones: | ||
| + | • ATP-binding pocket: is mainly mediated by alfa-helix | ||
| + | • Protein-binding pocket: is responsible of binding protein to be fosforilated | ||
Revision as of 17:25, 4 December 2012
ABL1, also known as Abelson kinase, is a non-receptor tyrosine kinase that plays a role in many key processes linked to cell growth and survival. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia.
Structure
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Catalytic domain
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Catalitic subunit of c-Abl protein is composed by two different regions:
Dentro del core de la akt, tenemos dos regiones: • ATP-binding pocket: is mainly mediated by alfa-helix • Protein-binding pocket: is responsible of binding protein to be fosforilated
