SandboxPKA

From Proteopedia

Revision as of 21:46, 4 December 2012

Introduction

The c-Abl protein 1 (ABL1), also known as Abelson kinase, is a non-receptor tyrosine kinase that plays a role in many key processes linked to cell growth and survival. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. In more than 90% cases, chronic myelogeneous leukemia (CML) is caused by chromosomal abnormality resulting in the formation of a so-called Philadelphia chromosome. It is caused by (9;22) chromosomal-translocation and results in the head-to-tail fusion of the BCR and ABL1, leading a constitutive activation of this tyrosine kinase.

Structure

kjnkjkj

Catalytic domain

It is responsible of both, ATP binding as well as protein binding.