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1rii
From Proteopedia
(New page: 200px<br /><applet load="1rii" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rii, resolution 1.70Å" /> '''Crystal structure of...) |
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| - | [[Image:1rii.gif|left|200px]]<br /><applet load="1rii" size=" | + | [[Image:1rii.gif|left|200px]]<br /><applet load="1rii" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1rii, resolution 1.70Å" /> | caption="1rii, resolution 1.70Å" /> | ||
'''Crystal structure of phosphoglycerate mutase from M. Tuberculosis'''<br /> | '''Crystal structure of phosphoglycerate mutase from M. Tuberculosis'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The single-crystal X-ray structure of phosphoglycerate mutase from | + | The single-crystal X-ray structure of phosphoglycerate mutase from Mycobacterium tuberculosis has been determined at a resolution of 1.70 angstroms. The C-terminal tail of each of the subunits is flexible and disordered; however, for one of the four chains (chain A) all but five residues of the chain could be modeled. Noteworthy features of the structure include the active site and a proline-rich segment in each monomer forming a short left-handed polyprolyl helix. These segments lie on the enzyme surface and could conceivably participate in protein-protein interactions. |
==About this Structure== | ==About this Structure== | ||
| - | 1RII is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] Full crystallographic information is available from [http:// | + | 1RII is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RII OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Pashkova, I.]] | [[Category: Pashkova, I.]] | ||
[[Category: Perry, J.]] | [[Category: Perry, J.]] | ||
| - | [[Category: Sawaya, M | + | [[Category: Sawaya, M R.]] |
| - | [[Category: TBSGC, TB | + | [[Category: TBSGC, TB Structural Genomics Consortium.]] |
[[Category: Wu, Y.]] | [[Category: Wu, Y.]] | ||
[[Category: GOL]] | [[Category: GOL]] | ||
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[[Category: tbsgc]] | [[Category: tbsgc]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:51:15 2008'' |
Revision as of 12:51, 21 February 2008
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Crystal structure of phosphoglycerate mutase from M. Tuberculosis
Overview
The single-crystal X-ray structure of phosphoglycerate mutase from Mycobacterium tuberculosis has been determined at a resolution of 1.70 angstroms. The C-terminal tail of each of the subunits is flexible and disordered; however, for one of the four chains (chain A) all but five residues of the chain could be modeled. Noteworthy features of the structure include the active site and a proline-rich segment in each monomer forming a short left-handed polyprolyl helix. These segments lie on the enzyme surface and could conceivably participate in protein-protein interactions.
About this Structure
1RII is a Single protein structure of sequence from Mycobacterium tuberculosis with as ligand. Active as Phosphoglycerate mutase, with EC number 5.4.2.1 Full crystallographic information is available from OCA.
Reference
The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase., Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D, Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):309-15. Epub 2005, Feb 24. PMID:15735341
Page seeded by OCA on Thu Feb 21 14:51:15 2008
Categories: Mycobacterium tuberculosis | Phosphoglycerate mutase | Single protein | Chan, S. | Eisenberg, D. | Mueller, P. | Pashkova, I. | Perry, J. | Sawaya, M R. | TBSGC, TB Structural Genomics Consortium. | Wu, Y. | GOL | Phosphoglyerate mutase | Protein structure initiative | Psi | Sh3 domain binding | Structural genomics | Tb structural genomics consortium | Tbsgc
