1rjb
From Proteopedia
(New page: 200px<br /> <applet load="1rjb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rjb, resolution 2.10Å" /> '''Crystal Structure o...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1rjb.gif|left|200px]]<br /> | + | [[Image:1rjb.gif|left|200px]]<br /><applet load="1rjb" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1rjb" size=" | + | |
caption="1rjb, resolution 2.10Å" /> | caption="1rjb, resolution 2.10Å" /> | ||
'''Crystal Structure of FLT3'''<br /> | '''Crystal Structure of FLT3'''<br /> | ||
==Overview== | ==Overview== | ||
| - | FLT3 is a type III receptor tyrosine kinase that is thought to play a key | + | FLT3 is a type III receptor tyrosine kinase that is thought to play a key role in hematopoiesis. Certain classes of FLT3 mutations cause constitutively activated forms of the receptor that are found in significant numbers of patients with acute myelogenous leukemia (AML). The mutations occur either in the activation loop, for example, as point mutations of Asp835 or as internal tandem duplication (ITD) sequences in the juxtamembrane (JM) domain. To further understand the nature of FLT3 autoinhibition and regulation, we have determined the crystal structure of the autoinhibited form of FLT3. This structure shows the autoinhibitory conformation of a complete JM domain in this class of receptor tyrosine kinases. The detailed inhibitory mechanism of the JM domain is revealed, which is likely utilized by other members of type III receptor tyrosine kinases. |
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1RJB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http:// | + | 1RJB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJB OCA]. |
==Reference== | ==Reference== | ||
| Line 31: | Line 30: | ||
[[Category: structure]] | [[Category: structure]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:51:28 2008'' |
Revision as of 12:51, 21 February 2008
|
Crystal Structure of FLT3
Contents |
Overview
FLT3 is a type III receptor tyrosine kinase that is thought to play a key role in hematopoiesis. Certain classes of FLT3 mutations cause constitutively activated forms of the receptor that are found in significant numbers of patients with acute myelogenous leukemia (AML). The mutations occur either in the activation loop, for example, as point mutations of Asp835 or as internal tandem duplication (ITD) sequences in the juxtamembrane (JM) domain. To further understand the nature of FLT3 autoinhibition and regulation, we have determined the crystal structure of the autoinhibited form of FLT3. This structure shows the autoinhibitory conformation of a complete JM domain in this class of receptor tyrosine kinases. The detailed inhibitory mechanism of the JM domain is revealed, which is likely utilized by other members of type III receptor tyrosine kinases.
Disease
Known diseases associated with this structure: Leukemia, acute lymphoblastic OMIM:[136351], Leukemia, acute myeloid OMIM:[136351], Leukemia, acute myeloid, reduced survival in OMIM:[136351], Melanoma, malignant sporadic OMIM:[602216], Pancreatic cancer, sporadic OMIM:[602216], Peutz-Jeghers syndrome OMIM:[602216], Testicular tumor, sporadic OMIM:[602216]
About this Structure
1RJB is a Single protein structure of sequence from Homo sapiens. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
Reference
The structural basis for autoinhibition of FLT3 by the juxtamembrane domain., Griffith J, Black J, Faerman C, Swenson L, Wynn M, Lu F, Lippke J, Saxena K, Mol Cell. 2004 Jan 30;13(2):169-78. PMID:14759363
Page seeded by OCA on Thu Feb 21 14:51:28 2008
Categories: Homo sapiens | Single protein | Transferase | Black, J. | Faerman, C. | Griffith, J. | Lippke, J. | Lu, F. | Saxena, K. | Swenson, L. | Wynn, M. | Autoinhibition | Juxtamembrane domain | Kinase | Structure
