1rxl
From Proteopedia
(New page: 200px<br /><applet load="1rxl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rxl" /> '''Solution structure of the engineered protein...) |
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'''Solution structure of the engineered protein Afae-dsc'''<br /> | '''Solution structure of the engineered protein Afae-dsc'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Pathogenic bacteria possess adhesion protein complexes that play essential | + | Pathogenic bacteria possess adhesion protein complexes that play essential roles in targeting host cells and in propagating infection. Although each family of adhesion proteins is generally associated with a specific human disease, the Dr family from Escherichia coli is a notable exception, as its members are associated with both diarrheal and urinary tract infections. These proteins are reported to form both fimbrial and afimbrial structures at the bacterial cell surface and target a common host cell receptor, the decay-accelerating factor (DAF or CD55). Using the newly solved three-dimensional structure of AfaE, we have constructed a robust atomic resolution model that reveals the structural basis for assembly by donor strand complementation and for the architecture of capped surface fibers. |
==About this Structure== | ==About this Structure== | ||
| - | 1RXL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http:// | + | 1RXL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Anderson, K | + | [[Category: Anderson, K L.]] |
| - | [[Category: Barlow, P | + | [[Category: Barlow, P N.]] |
[[Category: Billington, J.]] | [[Category: Billington, J.]] | ||
| - | [[Category: Bouguenec, C | + | [[Category: Bouguenec, C Le.]] |
| - | [[Category: Chen, H | + | [[Category: Chen, H A.]] |
[[Category: Cota, E]] | [[Category: Cota, E]] | ||
| - | [[Category: Lea, S | + | [[Category: Lea, S M.]] |
[[Category: Matthews, S.]] | [[Category: Matthews, S.]] | ||
| - | [[Category: Medof, M | + | [[Category: Medof, M E.]] |
| - | [[Category: Merle, L | + | [[Category: Merle, L du.]] |
[[Category: Nowicki, B.]] | [[Category: Nowicki, B.]] | ||
[[Category: Pettigrew, D.]] | [[Category: Pettigrew, D.]] | ||
[[Category: Roversi, P.]] | [[Category: Roversi, P.]] | ||
[[Category: Simpson, P.]] | [[Category: Simpson, P.]] | ||
| - | [[Category: Smith, R | + | [[Category: Smith, R A.]] |
[[Category: Urvil, P.]] | [[Category: Urvil, P.]] | ||
[[Category: afae]] | [[Category: afae]] | ||
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[[Category: upec]] | [[Category: upec]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:55:39 2008'' |
Revision as of 12:55, 21 February 2008
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Solution structure of the engineered protein Afae-dsc
Overview
Pathogenic bacteria possess adhesion protein complexes that play essential roles in targeting host cells and in propagating infection. Although each family of adhesion proteins is generally associated with a specific human disease, the Dr family from Escherichia coli is a notable exception, as its members are associated with both diarrheal and urinary tract infections. These proteins are reported to form both fimbrial and afimbrial structures at the bacterial cell surface and target a common host cell receptor, the decay-accelerating factor (DAF or CD55). Using the newly solved three-dimensional structure of AfaE, we have constructed a robust atomic resolution model that reveals the structural basis for assembly by donor strand complementation and for the architecture of capped surface fibers.
About this Structure
1RXL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
An atomic resolution model for assembly, architecture, and function of the Dr adhesins., Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RA, Nowicki B, Le Bouguenec C, Lea SM, Matthews S, Mol Cell. 2004 Aug 27;15(4):647-57. PMID:15327779
Page seeded by OCA on Thu Feb 21 14:55:39 2008
Categories: Escherichia coli | Single protein | Anderson, K L. | Barlow, P N. | Billington, J. | Bouguenec, C Le. | Chen, H A. | Cota, E | Lea, S M. | Matthews, S. | Medof, M E. | Merle, L du. | Nowicki, B. | Pettigrew, D. | Roversi, P. | Simpson, P. | Smith, R A. | Urvil, P. | Afae | Afimbrial sheath | Daec | Daf | Donor strand complemented | Ig-like domain | Nmr | Upec
