1rz7
From Proteopedia
(New page: 200px<br /> <applet load="1rz7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rz7, resolution 2.00Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1rz7.gif|left|200px]]<br /> | + | [[Image:1rz7.gif|left|200px]]<br /><applet load="1rz7" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1rz7" size=" | + | |
caption="1rz7, resolution 2.00Å" /> | caption="1rz7, resolution 2.00Å" /> | ||
'''CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 48D'''<br /> | '''CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 48D'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds | + | The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition. |
==About this Structure== | ==About this Structure== | ||
| - | 1RZ7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1RZ7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Choe, H.]] | [[Category: Choe, H.]] | ||
| - | [[Category: Dimitrov, D | + | [[Category: Dimitrov, D S.]] |
[[Category: Farzan, M.]] | [[Category: Farzan, M.]] | ||
| - | [[Category: Hendrickson, W | + | [[Category: Hendrickson, W A.]] |
| - | [[Category: Huang, C | + | [[Category: Huang, C C.]] |
| - | [[Category: Kwong, P | + | [[Category: Kwong, P D.]] |
[[Category: Majeed, S.]] | [[Category: Majeed, S.]] | ||
| - | [[Category: Moore, M | + | [[Category: Moore, M J.]] |
[[Category: Phogat, S.]] | [[Category: Phogat, S.]] | ||
[[Category: Robinson, J.]] | [[Category: Robinson, J.]] | ||
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[[Category: Venturi, M.]] | [[Category: Venturi, M.]] | ||
[[Category: Wyatt, R.]] | [[Category: Wyatt, R.]] | ||
| - | [[Category: Zhang, M | + | [[Category: Zhang, M Y.]] |
[[Category: GOL]] | [[Category: GOL]] | ||
[[Category: hiv-1; gp120; cd4i; antibodies; tyrosine sulfation; vh-gene usage]] | [[Category: hiv-1; gp120; cd4i; antibodies; tyrosine sulfation; vh-gene usage]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:56:09 2008'' |
Revision as of 12:56, 21 February 2008
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CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 48D
Overview
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
About this Structure
1RZ7 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267
Page seeded by OCA on Thu Feb 21 14:56:09 2008
Categories: Homo sapiens | Protein complex | Choe, H. | Dimitrov, D S. | Farzan, M. | Hendrickson, W A. | Huang, C C. | Kwong, P D. | Majeed, S. | Moore, M J. | Phogat, S. | Robinson, J. | Sodroski, J. | Venturi, M. | Wyatt, R. | Zhang, M Y. | GOL | Hiv-1; gp120; cd4i; antibodies; tyrosine sulfation; vh-gene usage
