1nc1
From Proteopedia
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===Crystal structure of E. coli MTA/AdoHcy nucleosidase complexed with 5'-methylthiotubercidin (MTH)=== | ===Crystal structure of E. coli MTA/AdoHcy nucleosidase complexed with 5'-methylthiotubercidin (MTH)=== | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[1nc1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NC1 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:012496243</ref><ref group="xtra">PMID:015122881</ref><ref group="xtra">PMID:016109423</ref><references group="xtra"/> |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Cornell, K A.]] | [[Category: Cornell, K A.]] | ||
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[[Category: Lee, J E.]] | [[Category: Lee, J E.]] | ||
[[Category: Riscoe, M K.]] | [[Category: Riscoe, M K.]] | ||
| + | [[Category: Hydrolase]] | ||
[[Category: Mixed alpha/beta dimer]] | [[Category: Mixed alpha/beta dimer]] | ||
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Revision as of 21:02, 5 December 2012
Crystal structure of E. coli MTA/AdoHcy nucleosidase complexed with 5'-methylthiotubercidin (MTH)
Template:ABSTRACT PUBMED 12496243
About this Structure
1nc1 is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Lee JE, Cornell KA, Riscoe MK, Howell PL. Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis. J Biol Chem. 2003 Mar 7;278(10):8761-70. Epub 2002 Dec 20. PMID:12496243 doi:10.1074/jbc.M210836200
- Lee JE, Settembre EC, Cornell KA, Riscoe MK, Sufrin JR, Ealick SE, Howell PL. Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design. Biochemistry. 2004 May 11;43(18):5159-69. PMID:15122881 doi:http://dx.doi.org/10.1021/bi035492h
- Lee JE, Smith GD, Horvatin C, Huang DJ, Cornell KA, Riscoe MK, Howell PL. Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis. J Mol Biol. 2005 Sep 23;352(3):559-74. PMID:16109423 doi:http://dx.doi.org/10.1016/j.jmb.2005.07.027
