Anthrax edema factor
From Proteopedia
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_1pk0| PDB=1pk0 | SIZE=400| SCENE= |right|CAPTION=EF trimer (grey, green, pink) complex with calmodulin (yellow, magenta, cyan) and | + | {{STRUCTURE_1pk0| PDB=1pk0 | SIZE=400| SCENE= |right|CAPTION=EF trimer (grey, green, pink) complex with calmodulin (yellow, magenta, cyan) and adenine diphosphate derivative, Ca+2 and Yt+3 ions [[1pk0]] }} |
<!-- | <!-- | ||
Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | ||
Revision as of 11:20, 11 December 2012
Template:STRUCTURE 1pk0 Anthrax edema factor (EF) is an enzyme which is part of the Bacillus anthracis anthrax toxin. The anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. It causes the cellular level of cAMP to increase thus upsetting water homeostasis and causing disruption of signaling pathways.
3D structures of anthrax edema factor
1lvc – EF adenylate cyclase domain + calmodulin + anthraniloyl-deoxy-ATP
1pk0 - EF adenylate cyclase domain + calmodulin + phosphonylmethoxyethyl-ADP
1s26 - EF adenylate cyclase domain + calmodulin + methylene-ATP
1sk6 - EF adenylate cyclase domain + calmodulin + pyrophosphate + cAMP
1xfu - EF residues 64-800 (mutant) + calmodulin
1xfv - EF residues 33-800 + calmodulin + deoxy-ATP
1xfw - EF residues 33-800 + calmodulin + cAMP
1xfx, 1xfy, 1xfz - EF residues 33-800 + calmodulin
