1sac
From Proteopedia
(New page: 200px<br /> <applet load="1sac" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sac, resolution 2.0Å" /> '''THE STRUCTURE OF PEN...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1sac.gif|left|200px]]<br /> | + | [[Image:1sac.gif|left|200px]]<br /><applet load="1sac" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1sac" size=" | + | |
caption="1sac, resolution 2.0Å" /> | caption="1sac, resolution 2.0Å" /> | ||
'''THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT'''<br /> | '''THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The three-dimensional structure of pentameric human serum amyloid P | + | The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gln 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils. |
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1SAC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1SAC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SAC OCA]. |
==Reference== | ==Reference== | ||
| Line 17: | Line 16: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Blundell, T | + | [[Category: Blundell, T L.]] |
[[Category: Emsley, J.]] | [[Category: Emsley, J.]] | ||
| - | [[Category: Hara, B | + | [[Category: Hara, B P.O.]] |
[[Category: Oliva, G.]] | [[Category: Oliva, G.]] | ||
| - | [[Category: Pepys, M | + | [[Category: Pepys, M B.]] |
[[Category: Srinivasan, N.]] | [[Category: Srinivasan, N.]] | ||
| - | [[Category: Tickle, I | + | [[Category: Tickle, I J.]] |
| - | [[Category: White, H | + | [[Category: White, H E.]] |
| - | [[Category: Wood, S | + | [[Category: Wood, S P.]] |
[[Category: ACY]] | [[Category: ACY]] | ||
[[Category: CA]] | [[Category: CA]] | ||
[[Category: amyloid protein]] | [[Category: amyloid protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:59:27 2008'' |
Revision as of 12:59, 21 February 2008
|
THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT
Contents |
Overview
The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gln 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.
Disease
Known disease associated with this structure: Amyloidosis, secondary, susceptibility to OMIM:[104770]
About this Structure
1SAC is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of pentameric human serum amyloid P component., Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP, Nature. 1994 Jan 27;367(6461):338-45. PMID:8114934
Page seeded by OCA on Thu Feb 21 14:59:27 2008
Categories: Homo sapiens | Single protein | Blundell, T L. | Emsley, J. | Hara, B P.O. | Oliva, G. | Pepys, M B. | Srinivasan, N. | Tickle, I J. | White, H E. | Wood, S P. | ACY | CA | Amyloid protein
