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1seb
From Proteopedia
(New page: 200px<br /> <applet load="1seb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1seb, resolution 2.7Å" /> '''COMPLEX OF THE HUMAN...) |
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| - | [[Image:1seb.gif|left|200px]]<br /> | + | [[Image:1seb.gif|left|200px]]<br /><applet load="1seb" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1seb" size=" | + | |
caption="1seb, resolution 2.7Å" /> | caption="1seb, resolution 2.7Å" /> | ||
'''COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB'''<br /> | '''COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of a bacterial superantigen, Staphylococcus aureus | + | The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a human class II histocompatibility complex molecule (HLA-DR1) has been determined by X-ray crystallography. The superantigen binds as an intact protein outside the conventional peptide antigen-binding site of the class II major histocompatibility complex (MHC) molecule. No large conformational changes occur upon complex formation in either the DR1 or the enterotoxin B molecules. The structure of the complex helps explain how different class II molecules and superantigens associate and suggests a model for ternary complex formation with the T-cell antigen receptor (TCR), in which unconventional TCR-MHC contacts are possible. |
==About this Structure== | ==About this Structure== | ||
| - | 1SEB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http:// | + | 1SEB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SEB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
| - | [[Category: Brown, J | + | [[Category: Brown, J H.]] |
| - | [[Category: Chi, Y | + | [[Category: Chi, Y I.]] |
| - | [[Category: Gorga, J | + | [[Category: Gorga, J C.]] |
| - | [[Category: Jardetzky, T | + | [[Category: Jardetzky, T S.]] |
[[Category: Stauffacher, C.]] | [[Category: Stauffacher, C.]] | ||
| - | [[Category: Stern, L | + | [[Category: Stern, L J.]] |
| - | [[Category: Strominger, J | + | [[Category: Strominger, J L.]] |
| - | [[Category: Urban, R | + | [[Category: Urban, R G.]] |
| - | [[Category: Wiley, D | + | [[Category: Wiley, D C.]] |
[[Category: enterotoxin peptide]] | [[Category: enterotoxin peptide]] | ||
[[Category: histocompatibility antigen]] | [[Category: histocompatibility antigen]] | ||
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[[Category: toxin]] | [[Category: toxin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:00:35 2008'' |
Revision as of 13:00, 21 February 2008
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COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB
Overview
The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a human class II histocompatibility complex molecule (HLA-DR1) has been determined by X-ray crystallography. The superantigen binds as an intact protein outside the conventional peptide antigen-binding site of the class II major histocompatibility complex (MHC) molecule. No large conformational changes occur upon complex formation in either the DR1 or the enterotoxin B molecules. The structure of the complex helps explain how different class II molecules and superantigens associate and suggests a model for ternary complex formation with the T-cell antigen receptor (TCR), in which unconventional TCR-MHC contacts are possible.
About this Structure
1SEB is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen., Jardetzky TS, Brown JH, Gorga JC, Stern LJ, Urban RG, Chi YI, Stauffacher C, Strominger JL, Wiley DC, Nature. 1994 Apr 21;368(6473):711-8. PMID:8152483
Page seeded by OCA on Thu Feb 21 15:00:35 2008
