1sfk

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(New page: 200px<br /><applet load="1sfk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sfk, resolution 3.20&Aring;" /> '''Core (C) protein fro...)
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[[Image:1sfk.gif|left|200px]]<br /><applet load="1sfk" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:1sfk.gif|left|200px]]<br /><applet load="1sfk" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1sfk, resolution 3.20&Aring;" />
caption="1sfk, resolution 3.20&Aring;" />
'''Core (C) protein from West Nile Virus, subtype Kunjin'''<br />
'''Core (C) protein from West Nile Virus, subtype Kunjin'''<br />
==Overview==
==Overview==
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We have determined the crystal structure of the core (C) protein from the, Kunjin subtype of West Nile virus (WNV), closely related to the NY99, strain of WNV, currently a major health threat in the U.S. WNV is a member, of the Flaviviridae family of enveloped RNA viruses that contains many, important human pathogens. The C protein is associated with the RNA genome, and forms the internal core which is surrounded by the envelope in the, virion. The C protein structure contains four alpha helices and forms, dimers that are organized into tetramers. The tetramers form extended, filamentous ribbons resembling the stacked alpha helices seen in HEAT, protein structures.
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We have determined the crystal structure of the core (C) protein from the Kunjin subtype of West Nile virus (WNV), closely related to the NY99 strain of WNV, currently a major health threat in the U.S. WNV is a member of the Flaviviridae family of enveloped RNA viruses that contains many important human pathogens. The C protein is associated with the RNA genome and forms the internal core which is surrounded by the envelope in the virion. The C protein structure contains four alpha helices and forms dimers that are organized into tetramers. The tetramers form extended filamentous ribbons resembling the stacked alpha helices seen in HEAT protein structures.
==About this Structure==
==About this Structure==
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1SFK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Kunjin_virus Kunjin virus] with CA, CL, PO4 and PG4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SFK OCA].
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1SFK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Kunjin_virus Kunjin virus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=PG4:'>PG4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SFK OCA].
==Reference==
==Reference==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Dokland, T.]]
[[Category: Dokland, T.]]
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[[Category: Ee, K.H.]]
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[[Category: Ee, K H.]]
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[[Category: Khromykh, A.A.]]
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[[Category: Khromykh, A A.]]
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[[Category: Mackenzie, J.M.]]
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[[Category: Mackenzie, J M.]]
[[Category: Walsh, M.]]
[[Category: Walsh, M.]]
[[Category: Wang, S.]]
[[Category: Wang, S.]]
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[[Category: alpha helix]]
[[Category: alpha helix]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:21:04 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:01:00 2008''

Revision as of 13:01, 21 February 2008

Image:1sfk.gif

1sfk, resolution 3.20Å

Drag the structure with the mouse to rotate

Core (C) protein from West Nile Virus, subtype Kunjin

Overview

We have determined the crystal structure of the core (C) protein from the Kunjin subtype of West Nile virus (WNV), closely related to the NY99 strain of WNV, currently a major health threat in the U.S. WNV is a member of the Flaviviridae family of enveloped RNA viruses that contains many important human pathogens. The C protein is associated with the RNA genome and forms the internal core which is surrounded by the envelope in the virion. The C protein structure contains four alpha helices and forms dimers that are organized into tetramers. The tetramers form extended filamentous ribbons resembling the stacked alpha helices seen in HEAT protein structures.

About this Structure

1SFK is a Single protein structure of sequence from Kunjin virus with , , and as ligands. Full crystallographic information is available from OCA.

Reference

West Nile virus core protein; tetramer structure and ribbon formation., Dokland T, Walsh M, Mackenzie JM, Khromykh AA, Ee KH, Wang S, Structure. 2004 Jul;12(7):1157-63. PMID:15242592

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