1sg1
From Proteopedia
(New page: 200px<br /> <applet load="1sg1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sg1, resolution 2.4Å" /> '''Crystal Structure of...) |
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| - | [[Image:1sg1.gif|left|200px]]<br /> | + | [[Image:1sg1.gif|left|200px]]<br /><applet load="1sg1" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1sg1" size=" | + | |
caption="1sg1, resolution 2.4Å" /> | caption="1sg1, resolution 2.4Å" /> | ||
'''Crystal Structure of the Receptor-Ligand Complex between Nerve Growth Factor and the Common Neurotrophin Receptor p75'''<br /> | '''Crystal Structure of the Receptor-Ligand Complex between Nerve Growth Factor and the Common Neurotrophin Receptor p75'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Neurotrophins are secreted growth factors critical for the development and | + | Neurotrophins are secreted growth factors critical for the development and maintenance of the vertebrate nervous system. Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor. We have determined the 2.4 A crystal structure of the prototypic neurotrophin, nerve growth factor (NGF), complexed with the extracellular domain of p75. Surprisingly, the complex is composed of an NGF homodimer asymmetrically bound to a single p75. p75 binds along the homodimeric interface of NGF, which disables NGF's symmetry-related second p75 binding site through an allosteric conformational change. Thus, neurotrophin signaling through p75 may occur by disassembly of p75 dimers and assembly of asymmetric 2:1 neurotrophin/p75 complexes, which could potentially engage a Trk receptor to form a trimolecular signaling complex. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SG1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CL as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1SG1 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb68_1.html Neurotrophins]]. Full crystallographic information is available from [http:// | + | 1SG1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1SG1 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb68_1.html Neurotrophins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Garcia, K | + | [[Category: Garcia, K C.]] |
| - | [[Category: He, X | + | [[Category: He, X L.]] |
[[Category: CL]] | [[Category: CL]] | ||
[[Category: common neurotrophin receptor]] | [[Category: common neurotrophin receptor]] | ||
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[[Category: receptor/ligand complex]] | [[Category: receptor/ligand complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:01:05 2008'' |
Revision as of 13:01, 21 February 2008
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Crystal Structure of the Receptor-Ligand Complex between Nerve Growth Factor and the Common Neurotrophin Receptor p75
Contents |
Overview
Neurotrophins are secreted growth factors critical for the development and maintenance of the vertebrate nervous system. Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor. We have determined the 2.4 A crystal structure of the prototypic neurotrophin, nerve growth factor (NGF), complexed with the extracellular domain of p75. Surprisingly, the complex is composed of an NGF homodimer asymmetrically bound to a single p75. p75 binds along the homodimeric interface of NGF, which disables NGF's symmetry-related second p75 binding site through an allosteric conformational change. Thus, neurotrophin signaling through p75 may occur by disassembly of p75 dimers and assembly of asymmetric 2:1 neurotrophin/p75 complexes, which could potentially engage a Trk receptor to form a trimolecular signaling complex.
Disease
Known disease associated with this structure: Neuropathy, hereditary sensory and autonomic, type V OMIM:[162030]
About this Structure
1SG1 is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus with as ligand. The following page contains interesting information on the relation of 1SG1 with [Neurotrophins]. Full crystallographic information is available from OCA.
Reference
Structure of nerve growth factor complexed with the shared neurotrophin receptor p75., He XL, Garcia KC, Science. 2004 May 7;304(5672):870-5. PMID:15131306
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