1sg7
From Proteopedia
(New page: 200px<br /><applet load="1sg7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sg7" /> '''NMR solution structure of the putative catio...) |
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| - | [[Image:1sg7.gif|left|200px]]<br /><applet load="1sg7" size=" | + | [[Image:1sg7.gif|left|200px]]<br /><applet load="1sg7" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''NMR solution structure of the putative cation transport regulator ChaB'''<br /> | '''NMR solution structure of the putative cation transport regulator ChaB'''<br /> | ||
==Overview== | ==Overview== | ||
| - | BACKGROUND: ChaB is a putative regulator of ChaA, a Na+/H+ antiporter that | + | BACKGROUND: ChaB is a putative regulator of ChaA, a Na+/H+ antiporter that also has Ca+/H+ activity in E. coli. ChaB contains a conserved 60-residue region of unknown function found in other bacteria, archaeabacteria and a series of baculoviral proteins. As part of a structural genomics project, the structure of ChaB was elucidated by NMR spectroscopy. RESULTS: The structure of ChaB is composed of 3 alpha-helices and a small sheet that pack tightly to form a fold that is found in the cyclin-box family of proteins. CONCLUSION: ChaB is distinguished from its putative DNA binding sequence homologues by a highly charged flexible loop region that has weak affinity to Mg2+ and Ca2+ divalent metal ions. |
==About this Structure== | ==About this Structure== | ||
| - | 1SG7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http:// | + | 1SG7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: BSGI, Montreal-Kingston | + | [[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]] |
[[Category: Cygler, M.]] | [[Category: Cygler, M.]] | ||
[[Category: Gehring, K.]] | [[Category: Gehring, K.]] | ||
| - | [[Category: Osborne, M | + | [[Category: Osborne, M J.]] |
[[Category: Siddiqui, N.]] | [[Category: Siddiqui, N.]] | ||
[[Category: bsgi]] | [[Category: bsgi]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:01:09 2008'' |
Revision as of 13:01, 21 February 2008
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NMR solution structure of the putative cation transport regulator ChaB
Overview
BACKGROUND: ChaB is a putative regulator of ChaA, a Na+/H+ antiporter that also has Ca+/H+ activity in E. coli. ChaB contains a conserved 60-residue region of unknown function found in other bacteria, archaeabacteria and a series of baculoviral proteins. As part of a structural genomics project, the structure of ChaB was elucidated by NMR spectroscopy. RESULTS: The structure of ChaB is composed of 3 alpha-helices and a small sheet that pack tightly to form a fold that is found in the cyclin-box family of proteins. CONCLUSION: ChaB is distinguished from its putative DNA binding sequence homologues by a highly charged flexible loop region that has weak affinity to Mg2+ and Ca2+ divalent metal ions.
About this Structure
1SG7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The solution structure of ChaB, a putative membrane ion antiporter regulator from Escherichia coli., Osborne MJ, Siddiqui N, Iannuzzi P, Gehring K, BMC Struct Biol. 2004 Aug 11;4:9. PMID:15306028
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