1skn
From Proteopedia
(New page: 200px<br /><applet load="1skn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1skn, resolution 2.500Å" /> '''THE BINDING DOMAIN ...) |
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| - | [[Image:1skn.gif|left|200px]]<br /><applet load="1skn" size=" | + | [[Image:1skn.gif|left|200px]]<br /><applet load="1skn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1skn, resolution 2.500Å" /> | caption="1skn, resolution 2.500Å" /> | ||
'''THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF'''<br /> | '''THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The DNA-binding domain of Skn-1, a developmental transcription factor that | + | The DNA-binding domain of Skn-1, a developmental transcription factor that specifies mesoderm in C. elegans, is shown by X-ray crystallography to have a novel fold in which a compact, monomeric, four-helix unit organizes two DNA-contact elements. At the C-terminus, a helix extends from the domain to occupy the major groove of DNA in a manner similar to bZip proteins. Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the 'homeodomain arm'. |
==About this Structure== | ==About this Structure== | ||
| - | 1SKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] with LDA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1SKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] with <scene name='pdbligand=LDA:'>LDA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bowerman, B.]] | [[Category: Bowerman, B.]] | ||
| - | [[Category: Daughdrill, G | + | [[Category: Daughdrill, G W.]] |
| - | [[Category: Matthews, B | + | [[Category: Matthews, B W.]] |
| - | [[Category: Rupert, P | + | [[Category: Rupert, P B.]] |
[[Category: LDA]] | [[Category: LDA]] | ||
[[Category: complex (transcription factor/dna)]] | [[Category: complex (transcription factor/dna)]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:02:27 2008'' |
Revision as of 13:02, 21 February 2008
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THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF
Overview
The DNA-binding domain of Skn-1, a developmental transcription factor that specifies mesoderm in C. elegans, is shown by X-ray crystallography to have a novel fold in which a compact, monomeric, four-helix unit organizes two DNA-contact elements. At the C-terminus, a helix extends from the domain to occupy the major groove of DNA in a manner similar to bZip proteins. Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the 'homeodomain arm'.
About this Structure
1SKN is a Single protein structure of sequence from Caenorhabditis elegans with as ligand. Full crystallographic information is available from OCA.
Reference
A new DNA-binding motif in the Skn-1 binding domain-DNA complex., Rupert PB, Daughdrill GW, Bowerman B, Matthews BW, Nat Struct Biol. 1998 Jun;5(6):484-91. PMID:9628487
Page seeded by OCA on Thu Feb 21 15:02:27 2008
