1skn

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(New page: 200px<br /><applet load="1skn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1skn, resolution 2.500&Aring;" /> '''THE BINDING DOMAIN ...)
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[[Image:1skn.gif|left|200px]]<br /><applet load="1skn" size="350" color="white" frame="true" align="right" spinBox="true"
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'''THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF'''<br />
'''THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF'''<br />
==Overview==
==Overview==
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The DNA-binding domain of Skn-1, a developmental transcription factor that, specifies mesoderm in C. elegans, is shown by X-ray crystallography to, have a novel fold in which a compact, monomeric, four-helix unit organizes, two DNA-contact elements. At the C-terminus, a helix extends from the, domain to occupy the major groove of DNA in a manner similar to bZip, proteins. Skn-1, however, lacks the leucine zipper found in all bZips., Additional contacts with the DNA are made by a short basic segment at the, N-terminus of the domain, reminiscent of the 'homeodomain arm'.
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The DNA-binding domain of Skn-1, a developmental transcription factor that specifies mesoderm in C. elegans, is shown by X-ray crystallography to have a novel fold in which a compact, monomeric, four-helix unit organizes two DNA-contact elements. At the C-terminus, a helix extends from the domain to occupy the major groove of DNA in a manner similar to bZip proteins. Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the 'homeodomain arm'.
==About this Structure==
==About this Structure==
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1SKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] with LDA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SKN OCA].
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1SKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] with <scene name='pdbligand=LDA:'>LDA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKN OCA].
==Reference==
==Reference==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Bowerman, B.]]
[[Category: Bowerman, B.]]
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[[Category: Daughdrill, G.W.]]
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[[Category: Daughdrill, G W.]]
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[[Category: Matthews, B.W.]]
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[[Category: Matthews, B W.]]
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[[Category: Rupert, P.B.]]
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[[Category: Rupert, P B.]]
[[Category: LDA]]
[[Category: LDA]]
[[Category: complex (transcription factor/dna)]]
[[Category: complex (transcription factor/dna)]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:26:29 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:02:27 2008''

Revision as of 13:02, 21 February 2008


1skn, resolution 2.500Å

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THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF

Overview

The DNA-binding domain of Skn-1, a developmental transcription factor that specifies mesoderm in C. elegans, is shown by X-ray crystallography to have a novel fold in which a compact, monomeric, four-helix unit organizes two DNA-contact elements. At the C-terminus, a helix extends from the domain to occupy the major groove of DNA in a manner similar to bZip proteins. Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the 'homeodomain arm'.

About this Structure

1SKN is a Single protein structure of sequence from Caenorhabditis elegans with as ligand. Full crystallographic information is available from OCA.

Reference

A new DNA-binding motif in the Skn-1 binding domain-DNA complex., Rupert PB, Daughdrill GW, Bowerman B, Matthews BW, Nat Struct Biol. 1998 Jun;5(6):484-91. PMID:9628487

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