1pl0
From Proteopedia
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[[Image:1pl0.png|left|200px]] | [[Image:1pl0.png|left|200px]] | ||
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{{STRUCTURE_1pl0| PDB=1pl0 | SCENE= }} | {{STRUCTURE_1pl0| PDB=1pl0 | SCENE= }} | ||
===Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC=== | ===Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC=== | ||
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{{ABSTRACT_PUBMED_14966129}} | {{ABSTRACT_PUBMED_14966129}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: AICA-ribosiduria due to ATIC deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601731 601731]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1pl0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL0 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:014966129</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Beardsley, G P.]] | [[Category: Beardsley, G P.]] | ||
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[[Category: Folate-based inhibitor]] | [[Category: Folate-based inhibitor]] | ||
[[Category: Human atic]] | [[Category: Human atic]] | ||
| + | [[Category: Hydrolase]] | ||
[[Category: Imp cyclohydrolase]] | [[Category: Imp cyclohydrolase]] | ||
| + | [[Category: Transferase]] | ||
[[Category: Xanthosine monophosphate]] | [[Category: Xanthosine monophosphate]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:19:06 2009'' | ||
Revision as of 11:57, 19 December 2012
Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC
Template:ABSTRACT PUBMED 14966129
About this Structure
1pl0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:14966129 doi:10.1074/jbc.M313691200
