1sui
From Proteopedia
(New page: 200px<br /><applet load="1sui" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sui, resolution 2.70Å" /> '''Alfalfa caffeoyl coe...) |
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| - | [[Image:1sui.gif|left|200px]]<br /><applet load="1sui" size=" | + | [[Image:1sui.gif|left|200px]]<br /><applet load="1sui" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1sui, resolution 2.70Å" /> | caption="1sui, resolution 2.70Å" /> | ||
'''Alfalfa caffeoyl coenzyme A 3-O-methyltransferase'''<br /> | '''Alfalfa caffeoyl coenzyme A 3-O-methyltransferase'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Caffeoyl coenzyme A 3-O-methyltransferases (CCoAOMTs) are | + | Caffeoyl coenzyme A 3-O-methyltransferases (CCoAOMTs) are S-adenosyl-l-methionine-dependent O-methyltransferases (OMTs) involved in lignin biosynthesis. Plant CCoAOMTs belong to a distinct family of OMTs, more closely related to the mammalian catechol OMTs than to other plant OMTs. The crystal structure of alfalfa (Medicago sativa) CCoAOMT in complex with the reaction products S-adenosine-l-homocysteine and feruloyl/sinapoyl CoAs presented here belong to a structurally and mechanistically distinct family of plant small molecule OMTs. These structures provide a new understanding of the substrate preferences and the catalytic mechanism accompanying CCoAOMT-mediated O-methylation of CoA-linked phenylpropanoid substrates. |
==About this Structure== | ==About this Structure== | ||
| - | 1SUI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa] with CA, SAH and FRE as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Caffeoyl-CoA_O-methyltransferase Caffeoyl-CoA O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.104 2.1.1.104] Full crystallographic information is available from [http:// | + | 1SUI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=SAH:'>SAH</scene> and <scene name='pdbligand=FRE:'>FRE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Caffeoyl-CoA_O-methyltransferase Caffeoyl-CoA O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.104 2.1.1.104] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Medicago sativa]] | [[Category: Medicago sativa]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Dixon, R | + | [[Category: Dixon, R A.]] |
| - | [[Category: Ferrer, J | + | [[Category: Ferrer, J L.]] |
| - | [[Category: Noel, J | + | [[Category: Noel, J P.]] |
[[Category: Zubieta, C.]] | [[Category: Zubieta, C.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: rossmann fold]] | [[Category: rossmann fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:05:19 2008'' |
Revision as of 13:05, 21 February 2008
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Alfalfa caffeoyl coenzyme A 3-O-methyltransferase
Overview
Caffeoyl coenzyme A 3-O-methyltransferases (CCoAOMTs) are S-adenosyl-l-methionine-dependent O-methyltransferases (OMTs) involved in lignin biosynthesis. Plant CCoAOMTs belong to a distinct family of OMTs, more closely related to the mammalian catechol OMTs than to other plant OMTs. The crystal structure of alfalfa (Medicago sativa) CCoAOMT in complex with the reaction products S-adenosine-l-homocysteine and feruloyl/sinapoyl CoAs presented here belong to a structurally and mechanistically distinct family of plant small molecule OMTs. These structures provide a new understanding of the substrate preferences and the catalytic mechanism accompanying CCoAOMT-mediated O-methylation of CoA-linked phenylpropanoid substrates.
About this Structure
1SUI is a Single protein structure of sequence from Medicago sativa with , and as ligands. Active as Caffeoyl-CoA O-methyltransferase, with EC number 2.1.1.104 Full crystallographic information is available from OCA.
Reference
Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase., Ferrer JL, Zubieta C, Dixon RA, Noel JP, Plant Physiol. 2005 Mar;137(3):1009-17. Epub 2005 Feb 25. PMID:15734921
Page seeded by OCA on Thu Feb 21 15:05:19 2008
