Sandbox UC 11

(Difference between revisions)

Revision as of 19:50, 19 December 2012

Structural annotation:
Resources:	CATH : 1Mnmc00, 1Mnmd00 InterPro : Ipr002100, Ipr001356, Ipr012287, Ipr009057 Pfam : PF00319, PF00046 SCOP : d1mnma_, d1mnmb_, d1mnmc_, d1mnmd_ UniProt : P11746, Q6B2C0

Functional annotation:
Cellular component:	nuclear chromatin nucleus
Biological process:	regulation of transcription from RNA polymerase II promoter cell cycle transcription DNA replication initiation regulation of transcription, DNA-dependent donor selection regulation of transcription
Molecular function:	DNA bending activity sequence-specific DNA binding transcription factor activity DNA replication origin binding DNA binding

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

YEAST MATALPHA2/MCM1/DNA TERNARY TRANSCRIPTION COMPLEX CRYSTAL STRUCTURE (PDB entry 1mnm)

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Kleanthous C, Kuhlmann UC, Pommer AJ, Ferguson N, Radford SE, Moore GR, James R, Hemmings AM. Structural and mechanistic basis of immunity toward endonuclease colicins. Nat Struct Biol. 1999 Mar;6(3):243-52. PMID:10074943 doi:http://dx.doi.org/10.1038/6683
Levin KB, Dym O, Albeck S, Magdassi S, Keeble AH, Kleanthous C, Tawfik DS. Following evolutionary paths to protein-protein interactions with high affinity and selectivity. Nat Struct Mol Biol. 2009 Oct;16(10):1049-55. Epub 2009 Sep 13. PMID:19749752 doi:10.1038/nsmb.1670

Marques SM, Esteves da Silva JC. Firefly bioluminescence: a mechanistic approach of luciferase catalyzed reactions. IUBMB Life. 2009 Jan;61(1):6-17. PMID:18949818 doi:10.1002/iub.134
Inouye S. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Cell Mol Life Sci. 2010 Feb;67(3):387-404. Epub 2009 Oct 27. PMID:19859663 doi:10.1007/s00018-009-0170-8

Amino Terminus

Carboxy Terminus

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-Hola vero<ref>pmid 1234</ref>
+<ref> '''MCM1''' bound to DNA  </ref>
 </StructureSection>