1sy6
From Proteopedia
(New page: 200px<br /> <applet load="1sy6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sy6, resolution 2.1Å" /> '''Crystal Structure of...) |
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| - | [[Image:1sy6.gif|left|200px]]<br /> | + | [[Image:1sy6.gif|left|200px]]<br /><applet load="1sy6" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1sy6" size=" | + | |
caption="1sy6, resolution 2.1Å" /> | caption="1sy6, resolution 2.1Å" /> | ||
'''Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment'''<br /> | '''Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The CD3 epsilon gamma heterodimer is essential for expression and function | + | The CD3 epsilon gamma heterodimer is essential for expression and function of the T cell receptor. The crystal structure of the human CD3 epsilon gamma heterodimer is described to 2.1-A resolution complexed with OKT3, a therapeutic mAb that not only activates and tolerizes mature T cells but also induces regulatory T cells. The mode of CD3 epsilon gamma dimerization provides a general structural basis for CD3 assembly and maps candidate T cell antigen receptor docking sites, including a duplicated linear region rich in acidic residues that is unique to human CD3 epsilon. OKT3 binds to an atypically small area of CD3 epsilon and has a low affinity for the isolated CD3 epsilon gamma heterodimer. The structure of the OKT3/CD3 epsilon gamma complex has implications for T cell signaling and therapeutic design. |
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| + | ==Disease== | ||
| + | Known disease associated with this structure: Immunodeficiency due to defect in CD3-epsilon OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186830 186830]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 1SY6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1SY6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SY6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Beddoe, T.]] | [[Category: Beddoe, T.]] | ||
| - | [[Category: Brooks, A | + | [[Category: Brooks, A G.]] |
| - | [[Category: Dunstone, M | + | [[Category: Dunstone, M A.]] |
| - | [[Category: Ely, L | + | [[Category: Ely, L K.]] |
[[Category: Kjer-Nielsen, L.]] | [[Category: Kjer-Nielsen, L.]] | ||
[[Category: Kostenko, L.]] | [[Category: Kostenko, L.]] | ||
[[Category: McCluskey, J.]] | [[Category: McCluskey, J.]] | ||
| - | [[Category: Misfud, N | + | [[Category: Misfud, N A.]] |
| - | [[Category: Purcell, A | + | [[Category: Purcell, A W.]] |
[[Category: Rossjohn, J.]] | [[Category: Rossjohn, J.]] | ||
[[Category: cd3 epsilon]] | [[Category: cd3 epsilon]] | ||
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[[Category: okt3 fab]] | [[Category: okt3 fab]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:07:00 2008'' |
Revision as of 13:07, 21 February 2008
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Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment
Contents |
Overview
The CD3 epsilon gamma heterodimer is essential for expression and function of the T cell receptor. The crystal structure of the human CD3 epsilon gamma heterodimer is described to 2.1-A resolution complexed with OKT3, a therapeutic mAb that not only activates and tolerizes mature T cells but also induces regulatory T cells. The mode of CD3 epsilon gamma dimerization provides a general structural basis for CD3 assembly and maps candidate T cell antigen receptor docking sites, including a duplicated linear region rich in acidic residues that is unique to human CD3 epsilon. OKT3 binds to an atypically small area of CD3 epsilon and has a low affinity for the isolated CD3 epsilon gamma heterodimer. The structure of the OKT3/CD3 epsilon gamma complex has implications for T cell signaling and therapeutic design.
Disease
Known disease associated with this structure: Immunodeficiency due to defect in CD3-epsilon OMIM:[186830]
About this Structure
1SY6 is a Single protein structure of sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3., Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J, Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10. PMID:15136729
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