This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Asparaginase
From Proteopedia
| Line 1: | Line 1: | ||
{{STRUCTURE_4gdv| PDB=4gdv | SIZE=400| SCENE= |right|CAPTION=Human asparaginase I dimer complex with aspartic acid and Na+ ions, [[4gdv]] }} | {{STRUCTURE_4gdv| PDB=4gdv | SIZE=400| SCENE= |right|CAPTION=Human asparaginase I dimer complex with aspartic acid and Na+ ions, [[4gdv]] }} | ||
| - | '''Asparaginase''' (ASP) | + | '''Asparaginase''' (ASP) catalyzes the conversion of asparagine to aspartic acid (AA). ASP I is used in the food processing industry to reduce the formation of the carcinogen acrylamide in the production of starchy food products. A different kind of ASP – ASP II – is used as drug (Elspar) in the treatment of cancer such as acute lymphoblastic leukemia (ALL). The ALL cells require high concentrations of asparagine which becomes scarce when high doses of ASP are present. |
==3D structures of asparaginase== | ==3D structures of asparaginase== | ||
Revision as of 11:04, 27 December 2012
Asparaginase (ASP) catalyzes the conversion of asparagine to aspartic acid (AA). ASP I is used in the food processing industry to reduce the formation of the carcinogen acrylamide in the production of starchy food products. A different kind of ASP – ASP II – is used as drug (Elspar) in the treatment of cancer such as acute lymphoblastic leukemia (ALL). The ALL cells require high concentrations of asparagine which becomes scarce when high doses of ASP are present.
Contents |
3D structures of asparaginase
ASP I
1hfj, 1hfk, 1o7j - ErcASP – Erwinia chrysanthemi
1wnf - ASP – Pyrococcus horikoshii
1zcf - PaASP – Pectobacterium atrosepticum
1gez - ASP – yellow lupine
2ocd - ASP – Vibrio cholera
2p2d - EcASP – Eschericia coli
3ntx - ASP – Yersinia pestis
3nxk - ASP – Campylobacter jejuni
4gdu - hASP – human
ASP I complex
1hfw - ErcASP + glutamate
2p2n - PaASP + glutamate
1hg0 - ErcASP + succinate
1hg1 - ErcASP + D-AA
2gvn - PaSP + AA
2jk0 - ASP + AA – Pectobacterium carotovorum
2wlt, 2wt4 - ASP + AA – Helicobacter pylori
2him, 2zal - EcASP + AA
2p2n - EcASP + asparagine + AA
1jsl, 1jsr - ErcASP + norleucine
4gdt - hASP + malonate
4gdv, 4gdw - hASP + AA
ASP II
1wsa – ASP precursor – Wolinella succinogenes
1ihd, 1jaz, 1jja - EcASP (mutant)
ASP II complex
3eca, 4eca, 1nns – EcASP + AA
1ho3 - EcASP (mutant) + AA
2zak, 3c17 - EcASP precursor (mutant)
Proteopedia Page Contributors and Editors (what is this?)
Joel L. Sussman, Michal Harel, Alexander Berchansky, Jaime Prilusky
