Glutaminase
From Proteopedia
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| - | + | {{STRUCTURE_3unw| PDB=3unw | SIZE=400| SCENE= |right|CAPTION=Human glutaminase tetramer complex with glutamate [[3unw]] }} | |
| - | {{STRUCTURE_3unw| PDB=3unw | SIZE=400| SCENE= |right|CAPTION=Human glutaminase complex with glutamate [[3unw]] }} | + | |
'''Glutaminase''' (GLN) catalyzes the conversion of glutamine (Gln) to glutamic acid (Glu). GLN is present at the axonal termini of neurons where GA functions as a neurotransmitter. ADP is an activator of GLN. GLN is a homodimer. In human GLN is found as 2 isozymes – GLN and GLN 2. Glutaminase-asparaginase (GLN-ASN) can amidohydrolase both glutamine and asparagine to their corresponding Glu and Asp. | '''Glutaminase''' (GLN) catalyzes the conversion of glutamine (Gln) to glutamic acid (Glu). GLN is present at the axonal termini of neurons where GA functions as a neurotransmitter. ADP is an activator of GLN. GLN is a homodimer. In human GLN is found as 2 isozymes – GLN and GLN 2. Glutaminase-asparaginase (GLN-ASN) can amidohydrolase both glutamine and asparagine to their corresponding Glu and Asp. | ||
Revision as of 11:47, 27 December 2012
Glutaminase (GLN) catalyzes the conversion of glutamine (Gln) to glutamic acid (Glu). GLN is present at the axonal termini of neurons where GA functions as a neurotransmitter. ADP is an activator of GLN. GLN is a homodimer. In human GLN is found as 2 isozymes – GLN and GLN 2. Glutaminase-asparaginase (GLN-ASN) can amidohydrolase both glutamine and asparagine to their corresponding Glu and Asp.
Contents |
3D structures of glutaminase
GLN
3if5, 3ih8, 3ih9, 3agd – MlGLN – Micrococcus luteus
3agf - BsGLN – Bacillus subtilis
3ss3, 3ss4 – mGLN C – mouse
3voy – hGLN – human
GLN complex
3brm – BsGLN + norleucine
3czd, 3unw – hGLN + Glu
3vp0 – hGLN + Gln
3uo9, 3voz, 3vp2, 3vp3, 3vp4 - hGLN + inhibitor
3iha, 3ihb, 3age - MlGLN + Glu
3ss5 – mGLN + Glu
3vp1 - hGLN + inhibitor + Glu
GLN-ASN
1agx – GLN-ASN – Acinetobacter glutaminacificans
3pga, 4pga – PsGLN-ASN – Pseudomonas
1djo, 1djp - PsGLN-ASN + norvaline derivative
1u60 - YbaS
3brm - YbgJ in a complex with DON
1mki - YbgJ free
Created with the participation of Lindsey Butler.
