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Revision as of 19:15, 30 December 2012

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spinqualitylabelsall models PDB ID 1j1c Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1j1c, resolution 2.10Å ()
Ligands:	,
Activity:	Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Related:	1j1b
Structural annotation: Resources: CATH : 1J1Ca02, 1J1Ca01, 1J1Cb02, 1J1Cb01 InterPro : Ipr011009, Ipr002290, Ipr008271, Ipr000719 Pfam : PF00069 SCOP : d1j1ca_, d1j1cb_ UniProt : P49841
Functional annotation: Cellular component: cytoplasm nucleus beta-catenin destruction complex Biological process: ER overload response positive regulation of protein export from nucleus peptidyl-serine phosphorylation glycogen metabolic process protein amino acid phosphorylation Wnt receptor signaling pathway through beta-catenin intracellular signaling cascade negative regulation of apoptosis Wnt receptor signaling pathway Molecular function: nucleotide binding kinase activity transferase activity ATP binding protein binding protein serine/threonine kinase activity NF-kappaB binding glycogen synthase kinase 3 activity protein kinase activity p53 binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Descritpion

Activity

at tyrosine-216 in GSK-3β or tyrosine-279 in GSK-3α enhances the enzymatic activity of GSK-3, while phosphorlyation of serine-9 in GSK-3β or serine-21 in GSK-3α significantly decreases active site availability

Structure

These are the engaged in the catalytic site of the protein, they are polar and localised in 3' end (Asp-181, Lys-183, Gln-185, Asn-186 and Ser-219. The Tau protein possesses as well as (Adenosine DiPhosphate) This enzyme is activated by phosphorylation at .

External Ressources

References