4dpf

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	{{STRUCTURE_4dpf| PDB=4dpf | SCENE= }}		{{STRUCTURE_4dpf| PDB=4dpf | SCENE= }}

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Revision as of 07:20, 2 January 2013

Template:STRUCTURE 4dpf

BACE-1 in complex with a HEA-macrocyclic type inhibitor

Template:ABSTRACT PUBMED 22698785

About this Structure

4dpf is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Sandgren V, Agback T, Johansson PO, Lindberg J, Kvarnstrom I, Samuelsson B, Belda O, Dahlgren A. Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes. Bioorg Med Chem. 2012 Jul 15;20(14):4377-89. Epub 2012 May 24. PMID:22698785 doi:10.1016/j.bmc.2012.05.039