1t7s
From Proteopedia
(New page: 200px<br /><applet load="1t7s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1t7s, resolution 2.80Å" /> '''Structural Genomics ...) |
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| - | [[Image:1t7s.gif|left|200px]]<br /><applet load="1t7s" size=" | + | [[Image:1t7s.gif|left|200px]]<br /><applet load="1t7s" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1t7s, resolution 2.80Å" /> | caption="1t7s, resolution 2.80Å" /> | ||
'''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''<br /> | '''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Binding of the BAG domain to the eukaryotic chaperone heat-shock protein | + | Binding of the BAG domain to the eukaryotic chaperone heat-shock protein (Hsp70) promotes ATP-dependent release of the protein substrate from Hsp70. Although the murine and human BAG domains have been shown to form an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain is formed by two antiparallel helices, while the third helix is extended away and stabilized by crystal-packing interactions. A small beta-sheet between helices 2 and 3 interferes with formation of the intramolecular three-helix bundle. However, intermolecular three-helix bundles are observed throughout the crystal packing and suggest that stable functional dimers and tetramers can be formed in solution. The structure may represent a new folding type of the BAG domain. |
==About this Structure== | ==About this Structure== | ||
| - | 1T7S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http:// | + | 1T7S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7S OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bunzel, R.]] | [[Category: Bunzel, R.]] | ||
[[Category: Li, S.]] | [[Category: Li, S.]] | ||
| - | [[Category: Luan, C | + | [[Category: Luan, C H.]] |
[[Category: Luo, M.]] | [[Category: Luo, M.]] | ||
[[Category: Pruett, P.]] | [[Category: Pruett, P.]] | ||
| - | [[Category: SECSG, Southeast | + | [[Category: SECSG, Southeast Collaboratory for Structural Genomics.]] |
[[Category: Schormann, N.]] | [[Category: Schormann, N.]] | ||
[[Category: Symersky, J.]] | [[Category: Symersky, J.]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:10:48 2008'' |
Revision as of 13:10, 21 February 2008
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Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein
Overview
Binding of the BAG domain to the eukaryotic chaperone heat-shock protein (Hsp70) promotes ATP-dependent release of the protein substrate from Hsp70. Although the murine and human BAG domains have been shown to form an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain is formed by two antiparallel helices, while the third helix is extended away and stabilized by crystal-packing interactions. A small beta-sheet between helices 2 and 3 interferes with formation of the intramolecular three-helix bundle. However, intermolecular three-helix bundles are observed throughout the crystal packing and suggest that stable functional dimers and tetramers can be formed in solution. The structure may represent a new folding type of the BAG domain.
About this Structure
1T7S is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.
Reference
Structural genomics of Caenorhabditis elegans: structure of the BAG domain., Symersky J, Zhang Y, Schormann N, Li S, Bunzel R, Pruett P, Luan CH, Luo M, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1606-10. Epub 2004, Aug 26. PMID:15333932
Page seeded by OCA on Thu Feb 21 15:10:48 2008
Categories: Caenorhabditis elegans | Single protein | Bunzel, R. | Li, S. | Luan, C H. | Luo, M. | Pruett, P. | SECSG, Southeast Collaboratory for Structural Genomics. | Schormann, N. | Symersky, J. | Zhang, Y. | Bag-1 cochaperone | Protein structure initiative | Psi | Secsg | Southeast collaboratory for structural genomics | Structural genomics
