1taf
From Proteopedia
(New page: 200px<br /><applet load="1taf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1taf, resolution 2.0Å" /> '''DROSOPHILA TBP ASSOCI...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1taf.gif|left|200px]]<br /><applet load="1taf" size=" | + | [[Image:1taf.gif|left|200px]]<br /><applet load="1taf" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1taf, resolution 2.0Å" /> | caption="1taf, resolution 2.0Å" /> | ||
'''DROSOPHILA TBP ASSOCIATED FACTORS DTAFII42/DTAFII62 HETEROTETRAMER'''<br /> | '''DROSOPHILA TBP ASSOCIATED FACTORS DTAFII42/DTAFII62 HETEROTETRAMER'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A complex of two TFIID TATA box-binding protein-associated factors (TA | + | A complex of two TFIID TATA box-binding protein-associated factors (TA FIIs) is described at 2.0A resolution. The amino-terminal portions of dTAFII42 and dTAFII62 from Drosophila adopt the canonical histone fold, consisting of two short alpha-helices flanking a long central alpha-helix. Like histones H3 and H4, dTAFII42 and dTAFII62 form an intimate heterodimer by extensive hydrophobic contacts between the paired molecules. In solution and in the crystalline state, the dTAFII42/dTAFII62 complex exists as a heterotetramer, resembling the (H3/H4)2 heterotetrameric core of the histone octamer, suggesting that TFIID contains a histone octamer-like substructure. |
==About this Structure== | ==About this Structure== | ||
| - | 1TAF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1TAF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TAF OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Burley, S | + | [[Category: Burley, S K.]] |
| - | [[Category: Chait, B | + | [[Category: Chait, B T.]] |
| - | [[Category: Cohen, S | + | [[Category: Cohen, S L.]] |
[[Category: Hoffmann, A.]] | [[Category: Hoffmann, A.]] | ||
[[Category: Kokubo, T.]] | [[Category: Kokubo, T.]] | ||
| - | [[Category: Mirza, U | + | [[Category: Mirza, U A.]] |
[[Category: Nakatani, Y.]] | [[Category: Nakatani, Y.]] | ||
| - | [[Category: Roeder, R | + | [[Category: Roeder, R G.]] |
[[Category: Xie, X.]] | [[Category: Xie, X.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
| Line 27: | Line 27: | ||
[[Category: transcription initiation]] | [[Category: transcription initiation]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:11:38 2008'' |
Revision as of 13:11, 21 February 2008
|
DROSOPHILA TBP ASSOCIATED FACTORS DTAFII42/DTAFII62 HETEROTETRAMER
Overview
A complex of two TFIID TATA box-binding protein-associated factors (TA FIIs) is described at 2.0A resolution. The amino-terminal portions of dTAFII42 and dTAFII62 from Drosophila adopt the canonical histone fold, consisting of two short alpha-helices flanking a long central alpha-helix. Like histones H3 and H4, dTAFII42 and dTAFII62 form an intimate heterodimer by extensive hydrophobic contacts between the paired molecules. In solution and in the crystalline state, the dTAFII42/dTAFII62 complex exists as a heterotetramer, resembling the (H3/H4)2 heterotetrameric core of the histone octamer, suggesting that TFIID contains a histone octamer-like substructure.
About this Structure
1TAF is a Protein complex structure of sequences from Drosophila melanogaster with as ligand. Full crystallographic information is available from OCA.
Reference
Structural similarity between TAFs and the heterotetrameric core of the histone octamer., Xie X, Kokubo T, Cohen SL, Mirza UA, Hoffmann A, Chait BT, Roeder RG, Nakatani Y, Burley SK, Nature. 1996 Mar 28;380(6572):316-22. PMID:8598927
Page seeded by OCA on Thu Feb 21 15:11:38 2008
