MECDP synthase
From Proteopedia
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| - | {{STRUCTURE_1gx1| PDB=1gx1 | SIZE=400| SCENE= |right|CAPTION=MECDP synthase | + | {{STRUCTURE_1gx1| PDB=1gx1 | SIZE=400| SCENE= |right|CAPTION=Se-Met MECDP synthase trimer complex with CDP, sulfate, Mn+2 (purple) and Zn+2 (grey) ion, [[1gx1]] }} |
'''MECDP synthase''' (MECPS) participates in mevalonate-independent steroid biosynthesis. It converts 2-phospho-4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol (2P-CDME) to 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate (MECP) and CMP. MECPS contains metal binding sites which are required for catalysis. MECPS is a potential antimalarial drug target. | '''MECDP synthase''' (MECPS) participates in mevalonate-independent steroid biosynthesis. It converts 2-phospho-4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol (2P-CDME) to 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate (MECP) and CMP. MECPS contains metal binding sites which are required for catalysis. MECPS is a potential antimalarial drug target. | ||
Revision as of 13:12, 2 January 2013
MECDP synthase (MECPS) participates in mevalonate-independent steroid biosynthesis. It converts 2-phospho-4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol (2P-CDME) to 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate (MECP) and CMP. MECPS contains metal binding sites which are required for catalysis. MECPS is a potential antimalarial drug target.
Contents |
3D structures of MECDP synthase
1knk - EcMECPS + Mn – Escherichia coli
1u3p - EcMECPS + Zn
3f0d - BpMECPS + Zn – Burkholderia pseudomallei
3f0e - BpMECPS + Mg + Zn
1jn1 - HiMECPS + Co – Haemophilus influenzae
1vh8 - HiMECPS
1vha - HiMECPS + Mn
1iv1 - TtMECPS – Thermus thermophilus
3f6m - YpMECPS – Yersinia pestis
1iv3 - TtMECPS (mutant) + Mg
3ghz - MECPS + Mg – Salmonella typhimurium
3re3 - MECPS – Francisella tularensis
MECPS binary complex
1gx1 - EcMECPS + CDP + Mn + Zn
1u3l - EcMECPS + CDP + Mg + Zn
3f0f - BpMECPS + CMP + Mg + Zn
3ike - BpMECPS + cytosine + Mg + Zn
3kix, 3ke1 - BpMECPS + cytosine derivative + Zn
3ikf, 3k14, 3q8h - BpMECPS + imidazo-thiazol derivative + Zn
3f0g, 3ieq - BpMECPS + CMP + Zn
2uzh - MECPS + CDP + Zn – Mycobacterium smegmatis
3fpi - YpMECPS + CTP + Mg
1iv2 - TtMECPS (mutant) + CDP + Mg
1iv4 - TtMECPS (mutant) + CMP + Mg
1h47 - EcMECPS + CMP + Zn
3jvh - BpMECPS + pyrimidine derivative + Zn
1u40 - EcMECPS + CDME + Zn
1u43 - EcMECPS + 2P-CDME
1t0a - MECPS + farnesyl phosphate + Co + Zn - Shewanella oneidensis
2pmp - MECPS + CMP + Zn – Arabidopsis thaliana
MECPS ternary complex
3iew - BpMECPS + CDP + CTP + Zn
1jy8 – EcMECPS + MECP + CMP + Zn
1knj - EcMECPS + MECP + CMP + Mn
3mbm - BpMECPS + imidazo-thiazol derivative +cytosine + Zn
3p10 - BpMECPS + pyrimidine derivative + cytidine + Zn
3t80 - MECPS + pyrimidine derivative + cytidine + Zn – Salmonella enterica
1yqn – EcMECPS (mutant) + CMP + geranyl diphosphate + Mn + Zn
2amt - EcMECPS + CMP derivative + geranyl diphosphate + Zn
3elc, 3eor, 3ern, 3fba - EcMECPS + pyrimidine derivative + geranyl diphosphate + Zn
3esj - EcMECPS + pyrimidine derivative + geranyl diphosphate + Mg + Zn
2gzl - EcMECPS + inhibitor + geranyl diphosphate + Zn
MECPS quaternary complex
3p0z, 3qhd - BpMECPS + imidazo derivative + pyrimidine derivative + cytidine + Zn
1h48 - EcMECPS + MECP + CMP + geranyl diphosphate + Mn + Zn
