1tf2
From Proteopedia
(New page: 200px<br /><applet load="1tf2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tf2, resolution 2.90Å" /> '''Crystal structure of...) |
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| - | [[Image:1tf2.jpg|left|200px]]<br /><applet load="1tf2" size=" | + | [[Image:1tf2.jpg|left|200px]]<br /><applet load="1tf2" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1tf2, resolution 2.90Å" /> | caption="1tf2, resolution 2.90Å" /> | ||
'''Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis'''<br /> | '''Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The ATPase SecA mediates the posttranslational translocation of a wide | + | The ATPase SecA mediates the posttranslational translocation of a wide range of polypeptide substrates through the SecY channel in the cytoplasmic membrane of bacteria. We have determined the crystal structure of a monomeric form of Bacillus subtilis SecA at a 2.2-A resolution. A comparison with the previously determined structures of SecA reveals a nucleotide-independent, large conformational change that opens a deep groove similar to that in other proteins that interact with diverse polypeptides. We propose that the open form of SecA represents an activated state. |
==About this Structure== | ==About this Structure== | ||
| - | 1TF2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with MG and ADP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1TF2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF2 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Jr., W | + | [[Category: Jr., W M.Clemons.]] |
| - | [[Category: Osborne, A | + | [[Category: Osborne, A R.]] |
| - | [[Category: Rapoport, T | + | [[Category: Rapoport, T A.]] |
[[Category: ADP]] | [[Category: ADP]] | ||
[[Category: MG]] | [[Category: MG]] | ||
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[[Category: translocation]] | [[Category: translocation]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:12:56 2008'' |
Revision as of 13:12, 21 February 2008
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Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis
Overview
The ATPase SecA mediates the posttranslational translocation of a wide range of polypeptide substrates through the SecY channel in the cytoplasmic membrane of bacteria. We have determined the crystal structure of a monomeric form of Bacillus subtilis SecA at a 2.2-A resolution. A comparison with the previously determined structures of SecA reveals a nucleotide-independent, large conformational change that opens a deep groove similar to that in other proteins that interact with diverse polypeptides. We propose that the open form of SecA represents an activated state.
About this Structure
1TF2 is a Single protein structure of sequence from Bacillus subtilis with and as ligands. Full crystallographic information is available from OCA.
Reference
A large conformational change of the translocation ATPase SecA., Osborne AR, Clemons WM Jr, Rapoport TA, Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10937-42. Epub 2004 Jul 15. PMID:15256599
Page seeded by OCA on Thu Feb 21 15:12:56 2008
Categories: Bacillus subtilis | Single protein | Jr., W M.Clemons. | Osborne, A R. | Rapoport, T A. | ADP | MG | Atpase | Helicase | Secretion | Translocation
