1r1w

(Difference between revisions)

Revision as of 09:58, 4 January 2013

1r1w, resolution 1.80Å ()

Gene:

MET (Homo sapiens)

Activity:

Related:

1r0p

Structural annotation:
Resources:	CATH : 1R1Wa02, 1R1Wa01 InterPro : Ipr003659, Ipr014756, Ipr002909, Ipr000719, Ipr008266, Ipr002165, Ipr001627, Ipr001245, Ipr011009 Pfam : PF07714 SCOP : d1r1wa_ UniProt : P08581

Functional annotation:
Cellular component:	membrane fraction integral to membrane membrane integral to plasma membrane basal plasma membrane
Biological process:	multicellular organismal development cell surface receptor linked signal transduction protein amino acid autophosphorylation cell proliferation brain development adult behavior activation of MAPK activity signal transduction protein amino acid phosphorylation hepatocyte growth factor receptor signaling pathway myoblast proliferation muscle development
Molecular function:	transferase activity receptor activity nucleotide binding hepatocyte growth factor receptor activity protein-tyrosine kinase activity kinase activity protein binding protein kinase activity ATP binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

1r1w is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12654-9. Epub 2003 Oct 14. PMID:14559966 doi:10.1073/pnas.1734128100