1tgh
From Proteopedia
(New page: 200px<br /> <applet load="1tgh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tgh, resolution 2.900Å" /> '''TATA BINDING PROTE...) |
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| - | [[Image:1tgh.gif|left|200px]]<br /> | + | [[Image:1tgh.gif|left|200px]]<br /><applet load="1tgh" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1tgh" size=" | + | |
caption="1tgh, resolution 2.900Å" /> | caption="1tgh, resolution 2.900Å" /> | ||
'''TATA BINDING PROTEIN (TBP)/DNA COMPLEX'''<br /> | '''TATA BINDING PROTEIN (TBP)/DNA COMPLEX'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of a complex of human TATA-binding protein with | + | The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TGH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1TGH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http:// | + | 1TGH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1TGH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGH OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: TATA-Binding Protein]] | [[Category: TATA-Binding Protein]] | ||
| - | [[Category: Dickerson, R | + | [[Category: Dickerson, R E.]] |
| - | [[Category: Juo, Z | + | [[Category: Juo, Z S.]] |
[[Category: dna]] | [[Category: dna]] | ||
[[Category: dna binding protein]] | [[Category: dna binding protein]] | ||
[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:15 2008'' |
Revision as of 13:13, 21 February 2008
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TATA BINDING PROTEIN (TBP)/DNA COMPLEX
Contents |
Overview
The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first.
Disease
Known diseases associated with this structure: Huntington disease-like-4 OMIM:[600075], Parkinson disease OMIM:[600075], Spinocerebellar ataxia 17 OMIM:[600075]
About this Structure
1TGH is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1TGH with [TATA-Binding Protein]. Full crystallographic information is available from OCA.
Reference
How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291
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