1tgh

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(New page: 200px<br /> <applet load="1tgh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tgh, resolution 2.900&Aring;" /> '''TATA BINDING PROTE...)
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caption="1tgh, resolution 2.900&Aring;" />
'''TATA BINDING PROTEIN (TBP)/DNA COMPLEX'''<br />
'''TATA BINDING PROTEIN (TBP)/DNA COMPLEX'''<br />
==Overview==
==Overview==
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The crystal structure of a complex of human TATA-binding protein with, TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses, from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight, into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a, particularly large minor groove ligand. This point of view provides, explanations for: (1) why T.A base-pairs are required rather than C.G; (2), why an alternation of T and A bases is needed; (3) how TBP recognizes the, upstream and downstream ends of the TATA box in order to bind properly;, and (4) why the second half of the TATA box can be more variable than the, first.
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The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first.
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1TGH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1TGH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TGH OCA].
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1TGH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1TGH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGH OCA].
==Reference==
==Reference==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: TATA-Binding Protein]]
[[Category: TATA-Binding Protein]]
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[[Category: Dickerson, R.E.]]
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[[Category: Dickerson, R E.]]
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[[Category: Juo, Z.S.]]
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[[Category: Juo, Z S.]]
[[Category: dna]]
[[Category: dna]]
[[Category: dna binding protein]]
[[Category: dna binding protein]]
[[Category: transcription factor]]
[[Category: transcription factor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:24:37 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:15 2008''

Revision as of 13:13, 21 February 2008


1tgh, resolution 2.900Å

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TATA BINDING PROTEIN (TBP)/DNA COMPLEX

Contents

Overview

The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first.

Disease

Known diseases associated with this structure: Huntington disease-like-4 OMIM:[600075], Parkinson disease OMIM:[600075], Spinocerebellar ataxia 17 OMIM:[600075]

About this Structure

1TGH is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1TGH with [TATA-Binding Protein]. Full crystallographic information is available from OCA.

Reference

How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291

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