1tnq
From Proteopedia
(New page: 200px<br /><applet load="1tnq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tnq" /> '''STRUCTURES OF THE APO AND CALCIUM TROPONIN-C...) |
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| - | [[Image:1tnq.jpg|left|200px]]<br /><applet load="1tnq" size=" | + | [[Image:1tnq.jpg|left|200px]]<br /><applet load="1tnq" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1tnq" /> | caption="1tnq" /> | ||
'''STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH'''<br /> | '''STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Regulation of contraction in skeletal muscle occurs through calcium | + | Regulation of contraction in skeletal muscle occurs through calcium binding to the protein troponin C. The solution structures of the regulatory domain of apo and calcium-loaded troponin C have been determined by multinuclear, multidimensional nuclear magnetic resonance techniques. The structural transition in the regulatory domain of troponin C on calcium binding involves an opening of the structure through large changes in interhelical angles. This leads to the increased exposure of an extensive hydrophobic patch, an event that triggers skeletal muscle contraction. |
==About this Structure== | ==About this Structure== | ||
| - | 1TNQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1TNQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TNQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Gagne, S | + | [[Category: Gagne, S M.]] |
| - | [[Category: Sykes, B | + | [[Category: Sykes, B D.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: ef-hand]] | [[Category: ef-hand]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:15:30 2008'' |
Revision as of 13:15, 21 February 2008
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STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH
Overview
Regulation of contraction in skeletal muscle occurs through calcium binding to the protein troponin C. The solution structures of the regulatory domain of apo and calcium-loaded troponin C have been determined by multinuclear, multidimensional nuclear magnetic resonance techniques. The structural transition in the regulatory domain of troponin C on calcium binding involves an opening of the structure through large changes in interhelical angles. This leads to the increased exposure of an extensive hydrophobic patch, an event that triggers skeletal muscle contraction.
About this Structure
1TNQ is a Single protein structure of sequence from Gallus gallus with as ligand. Full crystallographic information is available from OCA.
Reference
Structures of the troponin C regulatory domains in the apo and calcium-saturated states., Gagne SM, Tsuda S, Li MX, Smillie LB, Sykes BD, Nat Struct Biol. 1995 Sep;2(9):784-9. PMID:7552750
Page seeded by OCA on Thu Feb 21 15:15:30 2008
Categories: Gallus gallus | Single protein | Gagne, S M. | Sykes, B D. | CA | Ef-hand
