1fit

From Proteopedia

Revision as of 13:07, 30 October 2007

FHIT (FRAGILE HISTIDINE TRIAD PROTEIN)

Overview

BACKGROUND: The fragile histidine triad (FHIT) protein is a member of the, large and ubiquitous histidine triad (HIT) family of proteins. It is, expressed from a gene located at a fragile site on human chromosome 3, which is commonly disrupted in association with certain cancers. On the, basis of the genetic evidence, it has been postulated that the FHIT, protein may function as a tumor suppressor, implying a role for the FHIT, protein in carcinogenesis. The FHIT protein has dinucleoside polyphosphate, hydrolase activity in vitro, thus suggesting that its role in vivo may, involve the hydrolysis of a phosphoanhydride bond. The structural analysis, of FHIT will identify critical residues involved in substrate binding and, catalysis, and will provide insights into the in vivo function of ... [(full description)]

About this Structure

1FIT is a [Single protein] structure of sequence from [Homo sapiens] with FRU and SO4 as [ligands]. Structure known Active Site: AVE. Full crystallographic information is available from [OCA].

Reference

MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family., Lima CD, D'Amico KL, Naday I, Rosenbaum G, Westbrook EM, Hendrickson WA, Structure. 1997 Jun 15;5(6):763-74. PMID:9261067

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