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1u9k
From Proteopedia
(New page: 200px<br /><applet load="1u9k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1u9k, resolution 1.76Å" /> '''Crystal Structure of...) |
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| - | [[Image:1u9k.jpg|left|200px]]<br /><applet load="1u9k" size=" | + | [[Image:1u9k.jpg|left|200px]]<br /><applet load="1u9k" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1u9k, resolution 1.76Å" /> | caption="1u9k, resolution 1.76Å" /> | ||
'''Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76'''<br /> | '''Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Triggering receptor expressed on myeloid cells (TREM) 1 is an activating | + | Triggering receptor expressed on myeloid cells (TREM) 1 is an activating receptor expressed on myeloid cells whose ligand(s) remain elusive. TREM-1 stimulation activates neutrophils and monocytes and induces the secretion of pro-inflammatory molecules, which amplifies the Toll-like receptor-initiated responses to invading pathogens. In addition, TREM-1 mediates the septic shock pathway, and thus represents a potential therapeutic target. We report the crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution. The mouse extracellular domain is monomeric, consistent with our previous human TREM-1 structure, and strongly supports the contention that the globular TREM-1 head is a monomer contrary to proposals of a symmetric dimer. |
==About this Structure== | ==About this Structure== | ||
| - | 1U9K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1U9K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9K OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Debler, E | + | [[Category: Debler, E W.]] |
| - | [[Category: Kelker, M | + | [[Category: Kelker, M S.]] |
| - | [[Category: Wilson, I | + | [[Category: Wilson, I A.]] |
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: activating receptors]] | [[Category: activating receptors]] | ||
| Line 22: | Line 22: | ||
[[Category: trem-1]] | [[Category: trem-1]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:22:11 2008'' |
Revision as of 13:22, 21 February 2008
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Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76
Overview
Triggering receptor expressed on myeloid cells (TREM) 1 is an activating receptor expressed on myeloid cells whose ligand(s) remain elusive. TREM-1 stimulation activates neutrophils and monocytes and induces the secretion of pro-inflammatory molecules, which amplifies the Toll-like receptor-initiated responses to invading pathogens. In addition, TREM-1 mediates the septic shock pathway, and thus represents a potential therapeutic target. We report the crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution. The mouse extracellular domain is monomeric, consistent with our previous human TREM-1 structure, and strongly supports the contention that the globular TREM-1 head is a monomer contrary to proposals of a symmetric dimer.
About this Structure
1U9K is a Single protein structure of sequence from Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A., Kelker MS, Debler EW, Wilson IA, J Mol Biol. 2004 Dec 10;344(5):1175-81. PMID:15561137
Page seeded by OCA on Thu Feb 21 15:22:11 2008
