1uhn
From Proteopedia
(New page: 200px<br /><applet load="1uhn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uhn, resolution 2.1Å" /> '''The crystal structure...) |
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| - | [[Image:1uhn.jpg|left|200px]]<br /><applet load="1uhn" size=" | + | [[Image:1uhn.jpg|left|200px]]<br /><applet load="1uhn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1uhn, resolution 2.1Å" /> | caption="1uhn, resolution 2.1Å" /> | ||
'''The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana'''<br /> | '''The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Arabidopsis thaliana calcineurin B-like protein (AtCBL2) is a member of a | + | Arabidopsis thaliana calcineurin B-like protein (AtCBL2) is a member of a recently identified family of calcineurin B-like calcium-binding proteins in A. thaliana. The crystal structure of AtCBL2 has been determined at 2.1 A resolution. The protein forms a compact alpha-helical structure with two pairs of EF-hand motifs. The structure is similar in overall folding topology to the structures of calcineurin B and neuronal calcium sensor 1, but differs significantly in local conformation. The two calcium ions are coordinated in the first and fourth EF-hand motifs, whereas the second and third EF-hand motifs are maintained in the open form by internal hydrogen bonding without coordination of calcium ions. Both a possible site and a possible mechanism for the target binding to AtCBL2 are discussed based on the three-dimensional structure. |
==About this Structure== | ==About this Structure== | ||
| - | 1UHN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1UHN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: calcium binding protein]] | [[Category: calcium binding protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:24:37 2008'' |
Revision as of 13:24, 21 February 2008
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The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana
Overview
Arabidopsis thaliana calcineurin B-like protein (AtCBL2) is a member of a recently identified family of calcineurin B-like calcium-binding proteins in A. thaliana. The crystal structure of AtCBL2 has been determined at 2.1 A resolution. The protein forms a compact alpha-helical structure with two pairs of EF-hand motifs. The structure is similar in overall folding topology to the structures of calcineurin B and neuronal calcium sensor 1, but differs significantly in local conformation. The two calcium ions are coordinated in the first and fourth EF-hand motifs, whereas the second and third EF-hand motifs are maintained in the open form by internal hydrogen bonding without coordination of calcium ions. Both a possible site and a possible mechanism for the target binding to AtCBL2 are discussed based on the three-dimensional structure.
About this Structure
1UHN is a Single protein structure of sequence from Arabidopsis thaliana with as ligand. Full crystallographic information is available from OCA.
Reference
The crystal structure of the novel calcium-binding protein AtCBL2 from Arabidopsis thaliana., Nagae M, Nozawa A, Koizumi N, Sano H, Hashimoto H, Sato M, Shimizu T, J Biol Chem. 2003 Oct 24;278(43):42240-6. Epub 2003 Jul 19. PMID:12871972
Page seeded by OCA on Thu Feb 21 15:24:37 2008
