1ujl
From Proteopedia
(New page: 200px<br /> <applet load="1ujl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ujl" /> '''Solution Structure of the HERG K+ channel S...) |
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'''Solution Structure of the HERG K+ channel S5-P extracellular linker'''<br /> | '''Solution Structure of the HERG K+ channel S5-P extracellular linker'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The HERG K+ channel has very unusual kinetic behaviour that includes slow | + | The HERG K+ channel has very unusual kinetic behaviour that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarisation as well as in preventing lethal ventricular arrhythmias. Extensive mutagenesis of the HERG K+ channel has allowed identification of which regions of the channel are important for the unusual kinetic behaviour of the channel. Furthermore, structural studies on scorpion toxins that potently inhibit HERG are beginning to provide clues as to the structural differences between HERG and other voltage-gated K+ channels. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1UJL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1UJL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJL OCA]. |
==Reference== | ==Reference== | ||
The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics., Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW, Eur Biophys J. 2004 Apr;33(2):89-97. Epub 2003 Sep 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=13680209 13680209] | The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics., Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW, Eur Biophys J. 2004 Apr;33(2):89-97. Epub 2003 Sep 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=13680209 13680209] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Alewood, P | + | [[Category: Alewood, P F.]] |
| - | [[Category: Bansal, P | + | [[Category: Bansal, P S.]] |
[[Category: Bauskin, A.]] | [[Category: Bauskin, A.]] | ||
| - | [[Category: Breit, S | + | [[Category: Breit, S N.]] |
| - | [[Category: Bursill, J | + | [[Category: Bursill, J A.]] |
| - | [[Category: Campbell, T | + | [[Category: Campbell, T J.]] |
| - | [[Category: Clarke, C | + | [[Category: Clarke, C E.]] |
| - | [[Category: Kuchel, P | + | [[Category: Kuchel, P W.]] |
| - | [[Category: Smith, D | + | [[Category: Smith, D J.]] |
[[Category: Sunde, M.]] | [[Category: Sunde, M.]] | ||
| - | [[Category: Torres, A | + | [[Category: Torres, A M.]] |
| - | [[Category: Vandenberg, J | + | [[Category: Vandenberg, J I.]] |
[[Category: amphiphatic helix]] | [[Category: amphiphatic helix]] | ||
[[Category: two helices]] | [[Category: two helices]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:25:10 2008'' |
Revision as of 13:25, 21 February 2008
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Solution Structure of the HERG K+ channel S5-P extracellular linker
Contents |
Overview
The HERG K+ channel has very unusual kinetic behaviour that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarisation as well as in preventing lethal ventricular arrhythmias. Extensive mutagenesis of the HERG K+ channel has allowed identification of which regions of the channel are important for the unusual kinetic behaviour of the channel. Furthermore, structural studies on scorpion toxins that potently inhibit HERG are beginning to provide clues as to the structural differences between HERG and other voltage-gated K+ channels.
Disease
Known diseases associated with this structure: Lathosterolosis OMIM:[602286], Long QT syndrome, acquired, susceptibility to OMIM:[152427], Long QT syndrome-2 OMIM:[152427], Short QT syndrome-1 OMIM:[152427]
About this Structure
1UJL is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics., Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW, Eur Biophys J. 2004 Apr;33(2):89-97. Epub 2003 Sep 10. PMID:13680209
Page seeded by OCA on Thu Feb 21 15:25:10 2008
