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1gpj
From Proteopedia
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[[Category: trna-dependent tetrapyrrole biosynthesis]] | [[Category: trna-dependent tetrapyrrole biosynthesis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:16:42 2007'' |
Revision as of 13:11, 30 October 2007
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GLUTAMYL-TRNA REDUCTASE FROM METHANOPYRUS KANDLERI
Overview
Processes vital to life such as respiration and photosynthesis critically, depend on the availability of tetrapyrroles including hemes and, chlorophylls. tRNA-dependent catalysis generally is associated with, protein biosynthesis. An exception is the reduction of glutamyl-tRNA to, glutamate-1-semialdehyde by the enzyme glutamyl-tRNA reductase. This, reaction is the indispensable initiating step of tetrapyrrole biosynthesis, in plants and most prokaryotes. The crystal structure of glutamyl-tRNA, reductase from the archaeon Methanopyrus kandleri in complex with the, substrate-like inhibitor glutamycin at 1.9 A resolution reveals an, extended yet planar V-shaped dimer. The well defined interactions of the, inhibitor with the active site support a thioester-mediated reduction, process. ... [(full description)]
About this Structure
1GPJ is a [Single protein] structure of sequence from [Methanopyrus kandleri] with GMC and CIT as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
V-shaped structure of glutamyl-tRNA reductase, the first enzyme of tRNA-dependent tetrapyrrole biosynthesis., Moser J, Schubert WD, Beier V, Bringemeier I, Jahn D, Heinz DW, EMBO J. 2001 Dec 3;20(23):6583-90. PMID:11726494
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