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1uw1
From Proteopedia
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==Overview== | ==Overview== | ||
| - | A great challenge to biologists is to create proteins with novel folds and | + | A great challenge to biologists is to create proteins with novel folds and tailored functions. As an alternative to de novo protein design, we investigated the structure of a randomly generated protein targeted to bind ATP. The crystal structure reveals a novel alpha/beta fold bound to its ligand, representing both the first protein structure derived from in vitro evolution and the first nucleotide-binding protein stabilized by a zinc ion. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sollazzo, M.]] | [[Category: Sollazzo, M.]] | ||
| - | [[Category: Surdo, P | + | [[Category: Surdo, P Lo.]] |
| - | [[Category: Walsh, M | + | [[Category: Walsh, M A.]] |
[[Category: ADP]] | [[Category: ADP]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: nucleotide binding protein]] | [[Category: nucleotide binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:28:56 2008'' |
Revision as of 13:28, 21 February 2008
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A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION
Overview
A great challenge to biologists is to create proteins with novel folds and tailored functions. As an alternative to de novo protein design, we investigated the structure of a randomly generated protein targeted to bind ATP. The crystal structure reveals a novel alpha/beta fold bound to its ligand, representing both the first protein structure derived from in vitro evolution and the first nucleotide-binding protein stabilized by a zinc ion.
About this Structure
1UW1 is a Single protein structure of sequence from [1] with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384 [[Category: ]]
Page seeded by OCA on Thu Feb 21 15:28:56 2008
