2dxs
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:2dxs.png|left|200px]] | [[Image:2dxs.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2dxs", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2dxs| PDB=2dxs | SCENE= }} | {{STRUCTURE_2dxs| PDB=2dxs | SCENE= }} | ||
===Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor=== | ===Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_17125247}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 17125247 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_17125247}} | {{ABSTRACT_PUBMED_17125247}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2dxs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DXS OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017125247</ref><references group="xtra"/> |
[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
| Line 39: | Line 27: | ||
[[Category: Ns5b]] | [[Category: Ns5b]] | ||
[[Category: Rna polymerase]] | [[Category: Rna polymerase]] | ||
| - | + | [[Category: Transferase-transferase inhibitor complex]] | |
| - | + | ||
Revision as of 09:40, 6 January 2013
Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor
Template:ABSTRACT PUBMED 17125247
About this Structure
2dxs is a 2 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
- Ikegashira K, Oka T, Hirashima S, Noji S, Yamanaka H, Hara Y, Adachi T, Tsuruha J, Doi S, Hase Y, Noguchi T, Ando I, Ogura N, Ikeda S, Hashimoto H. Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors. J Med Chem. 2006 Nov 30;49(24):6950-3. PMID:17125247 doi:10.1021/jm0610245
