2b7a
From Proteopedia
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[[Image:2b7a.png|left|200px]] | [[Image:2b7a.png|left|200px]] | ||
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{{STRUCTURE_2b7a| PDB=2b7a | SCENE= }} | {{STRUCTURE_2b7a| PDB=2b7a | SCENE= }} | ||
===The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor=== | ===The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor=== | ||
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{{ABSTRACT_PUBMED_16174768}} | {{ABSTRACT_PUBMED_16174768}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myelofibrosis, idiopathic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myeloproliferative disorder with erythrocytosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Polycythemia vera OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Thrombocythemia, essential OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Budd-Chiari syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2b7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7A OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:016174768</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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[[Category: Wilks, A F.]] | [[Category: Wilks, A F.]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
| - | + | [[Category: Transferase]] | |
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Revision as of 09:58, 6 January 2013
The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
Template:ABSTRACT PUBMED 16174768
About this Structure
2b7a is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Lucet IS, Fantino E, Styles M, Bamert R, Patel O, Broughton SE, Walter M, Burns CJ, Treutlein H, Wilks AF, Rossjohn J. The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood. 2006 Jan 1;107(1):176-83. Epub 2005 Sep 20. PMID:16174768 doi:http://dx.doi.org/10.1182/blood-2005-06-2413
Categories: Homo sapiens | Transferase | Bamert, R. | Broughton, S E. | Burns, C J. | Fantino, E. | Lucet, I S. | Patel, O. | Rossjohn, J. | Styles, M. | Treutlein, H. | Walter, M. | Wilks, A F. | Kinase
