This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1vex
From Proteopedia
(New page: 200px<br /><applet load="1vex" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vex" /> '''F-spondin TSR domain 4'''<br /> ==Overview=...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1vex.gif|left|200px]]<br /><applet load="1vex" size=" | + | [[Image:1vex.gif|left|200px]]<br /><applet load="1vex" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1vex" /> | caption="1vex" /> | ||
'''F-spondin TSR domain 4'''<br /> | '''F-spondin TSR domain 4'''<br /> | ||
==Overview== | ==Overview== | ||
| - | F-spondin is a protein mainly associated with neuronal development. It | + | F-spondin is a protein mainly associated with neuronal development. It attaches to the extracellular matrix and acts in the axon guidance of the developing nervous system. F-spondin consists of eight domains, six of which are TSR domains. The TSR domain family binds a wide range of targets. Here we present the NMR solution structures of TSR1 and TSR4. TSR domains have an unusual fold that is characterized by a long, nonglobular shape, consisting of two beta-strands and one irregular extended strand. Three disulfide bridges and stack of alternating tryptophan and arginine side-chains stabilize the structure. TSR1 and TSR4 structures are similar to each other and to the previously determined TSR domain X-ray structures from another protein, TSP, although TSR4 exhibits a mobile loop not seen in other structures. |
==About this Structure== | ==About this Structure== | ||
| - | 1VEX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http:// | + | 1VEX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VEX OCA]. |
==Reference== | ==Reference== | ||
| Line 21: | Line 21: | ||
[[Category: tsr]] | [[Category: tsr]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:34:40 2008'' |
Revision as of 13:34, 21 February 2008
|
F-spondin TSR domain 4
Overview
F-spondin is a protein mainly associated with neuronal development. It attaches to the extracellular matrix and acts in the axon guidance of the developing nervous system. F-spondin consists of eight domains, six of which are TSR domains. The TSR domain family binds a wide range of targets. Here we present the NMR solution structures of TSR1 and TSR4. TSR domains have an unusual fold that is characterized by a long, nonglobular shape, consisting of two beta-strands and one irregular extended strand. Three disulfide bridges and stack of alternating tryptophan and arginine side-chains stabilize the structure. TSR1 and TSR4 structures are similar to each other and to the previously determined TSR domain X-ray structures from another protein, TSP, although TSR4 exhibits a mobile loop not seen in other structures.
About this Structure
1VEX is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Solution structures of the first and fourth TSR domains of F-spondin., Paakkonen K, Tossavainen H, Permi P, Rakkolainen H, Rauvala H, Raulo E, Kilpelainen I, Guntert P, Proteins. 2006 Aug 15;64(3):665-72. PMID:16736493
Page seeded by OCA on Thu Feb 21 15:34:40 2008
