1vex
From Proteopedia
(New page: 200px<br /><applet load="1vex" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vex" /> '''F-spondin TSR domain 4'''<br /> ==Overview=...) |
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| - | [[Image:1vex.gif|left|200px]]<br /><applet load="1vex" size=" | + | [[Image:1vex.gif|left|200px]]<br /><applet load="1vex" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''F-spondin TSR domain 4'''<br /> | '''F-spondin TSR domain 4'''<br /> | ||
==Overview== | ==Overview== | ||
| - | F-spondin is a protein mainly associated with neuronal development. It | + | F-spondin is a protein mainly associated with neuronal development. It attaches to the extracellular matrix and acts in the axon guidance of the developing nervous system. F-spondin consists of eight domains, six of which are TSR domains. The TSR domain family binds a wide range of targets. Here we present the NMR solution structures of TSR1 and TSR4. TSR domains have an unusual fold that is characterized by a long, nonglobular shape, consisting of two beta-strands and one irregular extended strand. Three disulfide bridges and stack of alternating tryptophan and arginine side-chains stabilize the structure. TSR1 and TSR4 structures are similar to each other and to the previously determined TSR domain X-ray structures from another protein, TSP, although TSR4 exhibits a mobile loop not seen in other structures. |
==About this Structure== | ==About this Structure== | ||
| - | 1VEX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http:// | + | 1VEX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VEX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: tsr]] | [[Category: tsr]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:34:40 2008'' |
Revision as of 13:34, 21 February 2008
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F-spondin TSR domain 4
Overview
F-spondin is a protein mainly associated with neuronal development. It attaches to the extracellular matrix and acts in the axon guidance of the developing nervous system. F-spondin consists of eight domains, six of which are TSR domains. The TSR domain family binds a wide range of targets. Here we present the NMR solution structures of TSR1 and TSR4. TSR domains have an unusual fold that is characterized by a long, nonglobular shape, consisting of two beta-strands and one irregular extended strand. Three disulfide bridges and stack of alternating tryptophan and arginine side-chains stabilize the structure. TSR1 and TSR4 structures are similar to each other and to the previously determined TSR domain X-ray structures from another protein, TSP, although TSR4 exhibits a mobile loop not seen in other structures.
About this Structure
1VEX is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Solution structures of the first and fourth TSR domains of F-spondin., Paakkonen K, Tossavainen H, Permi P, Rakkolainen H, Rauvala H, Raulo E, Kilpelainen I, Guntert P, Proteins. 2006 Aug 15;64(3):665-72. PMID:16736493
Page seeded by OCA on Thu Feb 21 15:34:40 2008
