1vhi
From Proteopedia
(New page: 200px<br /><applet load="1vhi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vhi, resolution 2.5Å" /> '''EPSTEIN BARR VIRUS NU...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1vhi.gif|left|200px]]<br /><applet load="1vhi" size=" | + | [[Image:1vhi.gif|left|200px]]<br /><applet load="1vhi" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1vhi, resolution 2.5Å" /> | caption="1vhi, resolution 2.5Å" /> | ||
'''EPSTEIN BARR VIRUS NUCLEAR ANTIGEN-1 DNA-BINDING DOMAIN, RESIDUES 470-607'''<br /> | '''EPSTEIN BARR VIRUS NUCLEAR ANTIGEN-1 DNA-BINDING DOMAIN, RESIDUES 470-607'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of the DNA-binding and dimerization domains of the | + | The crystal structure of the DNA-binding and dimerization domains of the Epstein-Barr virus nuclear antigen 1 (EBNA1), which binds to and activates DNA replication from the latent origin of replication in Epstein-Barr virus, was solved at 2.5 A resolution. EBNA1 appears to bind DNA via two independent regions termed the core and the flanking DNA-binding domains. The core DNA-binding domain, which comprises both the dimerization domain and a helix predicted to bind the inner portion of the EBNA1 DNA recognition element, was remarkably similar to the structure of the papillomavirus E2 protein, despite a complete lack of sequence conservation. The flanking DNA-binding domain, only a portion of which is contained in the current structure, consists in part of an alpha helix whose N-terminus contacts the outer regions of the EBNA1 DNA recognition element. |
==About this Structure== | ==About this Structure== | ||
| - | 1VHI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http:// | + | 1VHI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VHI OCA]. |
==Reference== | ==Reference== | ||
| Line 24: | Line 24: | ||
[[Category: origin-binding protein]] | [[Category: origin-binding protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:35:26 2008'' |
Revision as of 13:35, 21 February 2008
|
EPSTEIN BARR VIRUS NUCLEAR ANTIGEN-1 DNA-BINDING DOMAIN, RESIDUES 470-607
Overview
The crystal structure of the DNA-binding and dimerization domains of the Epstein-Barr virus nuclear antigen 1 (EBNA1), which binds to and activates DNA replication from the latent origin of replication in Epstein-Barr virus, was solved at 2.5 A resolution. EBNA1 appears to bind DNA via two independent regions termed the core and the flanking DNA-binding domains. The core DNA-binding domain, which comprises both the dimerization domain and a helix predicted to bind the inner portion of the EBNA1 DNA recognition element, was remarkably similar to the structure of the papillomavirus E2 protein, despite a complete lack of sequence conservation. The flanking DNA-binding domain, only a portion of which is contained in the current structure, consists in part of an alpha helix whose N-terminus contacts the outer regions of the EBNA1 DNA recognition element.
About this Structure
1VHI is a Single protein structure of sequence from Human herpesvirus 4. Full crystallographic information is available from OCA.
Reference
Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA 1., Bochkarev A, Barwell JA, Pfuetzner RA, Furey W Jr, Edwards AM, Frappier L, Cell. 1995 Oct 6;83(1):39-46. PMID:7553871
Page seeded by OCA on Thu Feb 21 15:35:26 2008
