1vp3
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1vp3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vp3, resolution 1.9Å" /> '''VACCINIA VIRUS PROTEI...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1vp3.jpg|left|200px]]<br /><applet load="1vp3" size=" | + | [[Image:1vp3.jpg|left|200px]]<br /><applet load="1vp3" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1vp3, resolution 1.9Å" /> | caption="1vp3, resolution 1.9Å" /> | ||
'''VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE'''<br /> | '''VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The specific binding of N7-methylguanine cap analogues to the RNA | + | The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap. |
==About this Structure== | ==About this Structure== | ||
| - | 1VP3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus] with SAH as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] Full crystallographic information is available from [http:// | + | 1VP3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus] with <scene name='pdbligand=SAH:'>SAH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VP3 OCA]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
| - | [[Category: Gershon, P | + | [[Category: Gershon, P D.]] |
| - | [[Category: Hodel, A | + | [[Category: Hodel, A E.]] |
| - | [[Category: Quiocho, F | + | [[Category: Quiocho, F A.]] |
[[Category: SAH]] | [[Category: SAH]] | ||
[[Category: methyltransferase]] | [[Category: methyltransferase]] | ||
| Line 25: | Line 25: | ||
[[Category: vaccinia]] | [[Category: vaccinia]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:37:13 2008'' |
Revision as of 13:37, 21 February 2008
|
VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE
Overview
The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.
About this Structure
1VP3 is a Single protein structure of sequence from Vaccinia virus with as ligand. Active as Polynucleotide adenylyltransferase, with EC number 2.7.7.19 Full crystallographic information is available from OCA.
Reference
Specific protein recognition of an mRNA cap through its alkylated base., Hodel AE, Gershon PD, Shi X, Wang SM, Quiocho FA, Nat Struct Biol. 1997 May;4(5):350-4. PMID:9145102
Page seeded by OCA on Thu Feb 21 15:37:13 2008
