2fb8
From Proteopedia
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{{STRUCTURE_2fb8| PDB=2fb8 | SCENE= }} | {{STRUCTURE_2fb8| PDB=2fb8 | SCENE= }} | ||
===Structure of the B-Raf kinase domain bound to SB-590885=== | ===Structure of the B-Raf kinase domain bound to SB-590885=== | ||
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{{ABSTRACT_PUBMED_17145850}} | {{ABSTRACT_PUBMED_17145850}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2fb8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FB8 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017145850</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
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[[Category: Stout, T J.]] | [[Category: Stout, T J.]] | ||
[[Category: Kinase domain]] | [[Category: Kinase domain]] | ||
| - | + | [[Category: Transferase]] | |
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Revision as of 11:05, 7 January 2013
Structure of the B-Raf kinase domain bound to SB-590885
Template:ABSTRACT PUBMED 17145850
About this Structure
2fb8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- King AJ, Patrick DR, Batorsky RS, Ho ML, Do HT, Zhang SY, Kumar R, Rusnak DW, Takle AK, Wilson DM, Hugger E, Wang L, Karreth F, Lougheed JC, Lee J, Chau D, Stout TJ, May EW, Rominger CM, Schaber MD, Luo L, Lakdawala AS, Adams JL, Contractor RG, Smalley KS, Herlyn M, Morrissey MM, Tuveson DA, Huang PS. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res. 2006 Dec 1;66(23):11100-5. PMID:17145850 doi:66/23/11100
