1vzv
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Varicella-zoster virus (VZV), an alpha-herpes virus, is the causative | + | Varicella-zoster virus (VZV), an alpha-herpes virus, is the causative agent of chickenpox, shingles, and postherpetic neuralgia. The three-dimensional crystal structure of the serine protease from VZV has been determined at 3.0-A resolution. The VZV protease is essential for the life cycle of the virus and is a potential target for therapeutic intervention. The structure reveals an overall fold that is similar to that recently reported for the serine protease from cytomegalovirus (CMV), a herpes virus of the beta subfamily. The VZV protease structure provides further evidence to support the finding that herpes virus proteases have a fold and active site distinct from other serine proteases. The VZV protease catalytic triad consists of a serine and two histidines. The distal histidine is proposed to properly orient the proximal histidine. The identification of an alpha-helical segment in the VZV protease that was mostly disordered in the CMV protease provides a better definition of the postulated active site cavity and reveals an elastase-like S' region. Structural differences between the VZV and CMV proteases also suggest potential differences in their oligomerization states. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Varicella-zoster virus (isolate 40a2)]] | [[Category: Varicella-zoster virus (isolate 40a2)]] | ||
| - | [[Category: Abdel-Meguid, S | + | [[Category: Abdel-Meguid, S S.]] |
| - | [[Category: Culp, J | + | [[Category: Culp, J S.]] |
[[Category: Debouck, C.]] | [[Category: Debouck, C.]] | ||
| - | [[Category: Jason, C | + | [[Category: Jason, C A.]] |
[[Category: Qiu, X.]] | [[Category: Qiu, X.]] | ||
| - | [[Category: Richardson, S | + | [[Category: Richardson, S B.]] |
| - | [[Category: Smith, W | + | [[Category: Smith, W W.]] |
[[Category: coat protein]] | [[Category: coat protein]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
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[[Category: viral protease]] | [[Category: viral protease]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:39:02 2008'' |
Revision as of 13:39, 21 February 2008
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STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE
Overview
Varicella-zoster virus (VZV), an alpha-herpes virus, is the causative agent of chickenpox, shingles, and postherpetic neuralgia. The three-dimensional crystal structure of the serine protease from VZV has been determined at 3.0-A resolution. The VZV protease is essential for the life cycle of the virus and is a potential target for therapeutic intervention. The structure reveals an overall fold that is similar to that recently reported for the serine protease from cytomegalovirus (CMV), a herpes virus of the beta subfamily. The VZV protease structure provides further evidence to support the finding that herpes virus proteases have a fold and active site distinct from other serine proteases. The VZV protease catalytic triad consists of a serine and two histidines. The distal histidine is proposed to properly orient the proximal histidine. The identification of an alpha-helical segment in the VZV protease that was mostly disordered in the CMV protease provides a better definition of the postulated active site cavity and reveals an elastase-like S' region. Structural differences between the VZV and CMV proteases also suggest potential differences in their oligomerization states.
About this Structure
1VZV is a Single protein structure of sequence from Varicella-zoster virus (isolate 40a2). Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of varicella-zoster virus protease., Qiu X, Janson CA, Culp JS, Richardson SB, Debouck C, Smith WW, Abdel-Meguid SS, Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2874-9. PMID:9096314
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