2o8e
From Proteopedia
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{{STRUCTURE_2o8e| PDB=2o8e | SCENE= }} | {{STRUCTURE_2o8e| PDB=2o8e | SCENE= }} | ||
===human MutSalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only=== | ===human MutSalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only=== | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Colorectal cancer, hereditary nonpolyposis, type 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]], Mismatch repair cancer syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]], Muir-Torre syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2o8e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8E OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017531815</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Beese, L S.]] | [[Category: Beese, L S.]] | ||
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[[Category: Abc transporter atpase]] | [[Category: Abc transporter atpase]] | ||
[[Category: Cancer]] | [[Category: Cancer]] | ||
| + | [[Category: Dna binding protein-dna complex]] | ||
[[Category: Dna damage response]] | [[Category: Dna damage response]] | ||
[[Category: Dna mismatch repair]] | [[Category: Dna mismatch repair]] | ||
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[[Category: Protein-dna complex]] | [[Category: Protein-dna complex]] | ||
[[Category: Somatic hypermutation]] | [[Category: Somatic hypermutation]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:31:52 2009'' | ||
Revision as of 11:32, 7 January 2013
human MutSalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only
Template:ABSTRACT PUBMED 17531815
About this Structure
2o8e is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Warren JJ, Pohlhaus TJ, Changela A, Iyer RR, Modrich PL, Beese LS. Structure of the human MutSalpha DNA lesion recognition complex. Mol Cell. 2007 May 25;26(4):579-92. PMID:17531815 doi:10.1016/j.molcel.2007.04.018
