1w33
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Borrelia burgdorferi, a spirochete transmitted to human hosts during | + | Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Brade, V.]] | [[Category: Brade, V.]] | ||
| - | [[Category: Cordes, F | + | [[Category: Cordes, F S.]] |
[[Category: Goodstadt, L.]] | [[Category: Goodstadt, L.]] | ||
[[Category: Kirschfink, M.]] | [[Category: Kirschfink, M.]] | ||
[[Category: Kraiczy, P.]] | [[Category: Kraiczy, P.]] | ||
| - | [[Category: Lea, S | + | [[Category: Lea, S M.]] |
[[Category: Ponting, C.]] | [[Category: Ponting, C.]] | ||
[[Category: Roversi, P.]] | [[Category: Roversi, P.]] | ||
| - | [[Category: Simon, M | + | [[Category: Simon, M M.]] |
[[Category: Skerka, C.]] | [[Category: Skerka, C.]] | ||
[[Category: Wallich, R.]] | [[Category: Wallich, R.]] | ||
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[[Category: tick]] | [[Category: tick]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:39:55 2008'' |
Revision as of 13:40, 21 February 2008
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BBCRASP-1 FROM BORRELIA BURGDORFERI
Overview
Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design.
About this Structure
1W33 is a Single protein structure of sequence from Borrelia burgdorferi with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi., Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM, Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564
Page seeded by OCA on Thu Feb 21 15:39:55 2008
Categories: Borrelia burgdorferi | Single protein | Brade, V. | Cordes, F S. | Goodstadt, L. | Kirschfink, M. | Kraiczy, P. | Lea, S M. | Ponting, C. | Roversi, P. | Simon, M M. | Skerka, C. | Wallich, R. | Zipfel, P. | GOL | Complement regulator acquiring surface protein | Factor h binding | Lyme borreliosis | Membrane protein | Tick
