1w4r
From Proteopedia
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
| - | The structure of human cytosolic thymidine kinase in complex with its | + | The structure of human cytosolic thymidine kinase in complex with its feedback inhibitor 2'-deoxythymidine-5'-triphosphate was determined. This structure is the first representative of the type II thymidine kinases found in several pathogens. The structure deviates strongly from the known structures of type I thymidine kinases such as the Herpes simplex enzyme. It contains a zinc-binding domain with four cysteines complexing a structural zinc ion. Interestingly, the backbone atoms of the type II enzyme bind thymine via hydrogen-bonds, in contrast to type I, where side chains are involved. This results in a specificity difference exploited for antiviral therapy. The presented structure will foster the development of new drugs and prodrugs for numerous therapeutic applications. |
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 14: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thymidine kinase]] | [[Category: Thymidine kinase]] | ||
| - | [[Category: Birringer, M | + | [[Category: Birringer, M S.]] |
| - | [[Category: Claus, M | + | [[Category: Claus, M T.]] |
[[Category: Folkers, G.]] | [[Category: Folkers, G.]] | ||
| - | [[Category: Kloer, D | + | [[Category: Kloer, D P.]] |
[[Category: Scapozza, L.]] | [[Category: Scapozza, L.]] | ||
| - | [[Category: Schulz, G | + | [[Category: Schulz, G E.]] |
[[Category: DTU]] | [[Category: DTU]] | ||
[[Category: TTP]] | [[Category: TTP]] | ||
| Line 31: | Line 31: | ||
[[Category: type ii]] | [[Category: type ii]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:40:27 2008'' |
Revision as of 13:40, 21 February 2008
|
STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP
Overview
The structure of human cytosolic thymidine kinase in complex with its feedback inhibitor 2'-deoxythymidine-5'-triphosphate was determined. This structure is the first representative of the type II thymidine kinases found in several pathogens. The structure deviates strongly from the known structures of type I thymidine kinases such as the Herpes simplex enzyme. It contains a zinc-binding domain with four cysteines complexing a structural zinc ion. Interestingly, the backbone atoms of the type II enzyme bind thymine via hydrogen-bonds, in contrast to type I, where side chains are involved. This results in a specificity difference exploited for antiviral therapy. The presented structure will foster the development of new drugs and prodrugs for numerous therapeutic applications.
About this Structure
1W4R is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Thymidine kinase, with EC number 2.7.1.21 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of a type II thymidine kinase with bound dTTP., Birringer MS, Claus MT, Folkers G, Kloer DP, Schulz GE, Scapozza L, FEBS Lett. 2005 Feb 28;579(6):1376-82. PMID:15733844
Page seeded by OCA on Thu Feb 21 15:40:27 2008
Categories: Homo sapiens | Single protein | Thymidine kinase | Birringer, M S. | Claus, M T. | Folkers, G. | Kloer, D P. | Scapozza, L. | Schulz, G E. | DTU | TTP | ZN | Cytosolic | Human | Kinase | Phosphorylation | Transferase | Type ii
